Taking Nyquil With Mucinex

In our latest question and answer, the pharmacist discusses whether or not it is safe to take Nyquil with Mucinex.


Hello, I have a terrible cold and want to know if you can take Mucinex with Nyquil?

Asked by Yolanda On Jan 21, 2022

Answered by
Medical Content Reviewed By HelloPharmacist Staff

Published Jan 21, 2022
Last updated Jul 18, 2024

Key points

  • There is no known drug interaction between NyQuil and Mucinex (guaifenesin). They are safe to take together.

Hello and thanks for your question!

The answer to this one is straightforward, Mucinex (guaifenesin) can be safely taken with Nyquil. There is no listed or reported interaction between the two drugs.

In the next sections, I discuss both in a little more detail.

Mucinex Information

Mucinex (guaifenesin) is an expectorant that thins and loosens mucus (i.e. phlegm) in the throat and chest area.

As a result, bronchial secretions/fluids are less viscous (i.e. thick) and are less likely to stick in the airways. This allows you to more easily expectorate the mucus.

Based on the expectorant actions of Mucinex, it can be beneficial for reducing cough associated with postnasal drip.

Mucinex is typically very well tolerated and has minimal side effects.

Branded Mucinex products (i.e. Mucinex 12 Hour) are 'dual-layer' tablets. One part of the tablet dissolves quickly, for a fast effect, while the other layer dissolves slowly, to allow for an extended-release effect.

Mucinex begins to work in about 20 to 30 minutes after taking a dose and lasts about 12 hours.

There are 'immediate-release' products on the market as well, and these last about 4-6 hours per dose.

Mucinex is a very common ingredient in combination cough/cold products, so it is important to be prudent and look at the 'drug facts' label on each product you are using to avoid doubling up on the medication.

Nyquil Information

Nyquil is a family of products that contain a variety of medications indicated for the treatment of cold/flu symptoms. Nyquil products also contain doxylamine, a sedating antihistamine.

There are a variety of Nyquil products available on the market in the United States, including:

  • Nyquil
  • Nyquil Cough
  • Nyquil Sinus
  • Nyquil D
  • NyQuil Severe

Nyquil, the original and most commonly used product, contains the following ingredients:

  • Acetaminophen (analgesic)
  • Dextromethorphan (cough suppressant)
  • Doxylamine (sedating antihistamine)

The other Nyquil products contain similar ingredients, with the main difference being whether or not they include a decongestant (e.g. phenylephrine, pseudoephedrine). None of the Nyquil products contain guaifenesin so there is no issue with taking too much of that ingredient when combining Nyquil and Mucinex.

Final Words

As mentioned above, there is no interaction between Mucinex and any of the Nyquil products. They may be safely taken together.

In fact, many of the ingredients found in Nyquil are often included in other combination cough/cold products that also contain guaifenesin.

Thanks again for your question!


About the Pharmacist

Dr. Brian Staiger, PharmD

Dr. Brian has been practicing pharmacy for over 13 years and has wide-ranging experiences in many different areas of the profession. From retail, clinical, program development, and administrative responsibilities, he's your knowledgeable and go-to source for all your pharmacy and medication-related questions! Dr. Brian Staiger also has herbalist training and educational certificates in the field of medical ethnobotany. Feel free to send him an email at [email protected]! You can also connect with Dr. Brian Staiger on LinkedIn.

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