What Cold Medicines Can You Take With Paxil?

Answer

It is always a good idea to check into potential drug interactions when considering over-the-counter cold medications, especially when you are taking antidepressants like Paxil (paroxetine).

Paxil is an SSRI (selective serotonin reuptake inhibitor) that does have a few drug interactions and considerations with over-the-counter medication that are important to be aware of.

There are many that are safe to take. They include:

• Antihistamines (e.g. Claritin, Allegra, Benadryl, Zyrtec etc...)
• Tylenol (acetaminophen)
• Mucinex (guaifenesin)
• Zinc/Vitamins

However, you also need to know the ones that may not be safe. These include:

• NSAIDs (e.g. ibuprofen, naproxen)
• Delsym (dextromethorphan)

Cold Meds Safe With Paxil

Antihistamines

Antihistamines are among the most commonly used over-the-counter medications used to treat cold symptoms.

They can help to relieve a runny nose, and watery eyes and dry your sinuses. 'First-generation' antihistamines are sedating and can be used to help you fall asleep at night.

There are no interactions between Paxil and any of the common over-the-counter antihistamines, which include:

• Claritin (loratadine)
• Zyrtec (cetirizine)
• Benadryl (diphenhydramine)
• Allegra (fexofenadine)
• Chlor-Trimeton (chlorpheniramine)
• Doxylamine

It is important to note that if Paxil makes you drowsy (a possible side effect), some of the antihistamines may cause additive drowsiness. This is particularly true of the 'first-generation' antihistamines, like Benadryl.

Tylenol (Acetaminophen)

When it comes to analgesics and fever reducers, it is better to use Tylenol rather than an NSAID like ibuprofen.

The potential issue with NSAIDs is described below but know that Paxil has no drug interaction with Tylenol and is safe to use.

Mucinex (Guaifenesin)

Mucinex is an expectorant that can help to relieve chest congestion, ease respiration and reduce post-nasal drip.

Mucinex has very few drug interactions and is safe to use with Paxil.

Zinc/Vitamin C

Zinc and vitamin C do not interact with Paxil. They are considered safe to use.

Cold Meds To Be Cautious With

NSAIDs

NSAIDs (e.g. Ibuprofen, Naproxen, Aspirin) need to be used cautiously will all SSRIs, including Paxil and there is an increased risk of stomach bleeds. This risk is further increased if you have had a history of stomach bleeds or ulcerations in the past. 

Intermittent use of NSAIDs and SSRIs may be safe, but they should only be combined if recommended by your doctor.

Dextromethorphan

Dextromethorphan (Delsym) is a cough suppressant that is a common ingredient in several over-the-counter cough/cold products. Caution should be taken when using Paxil and dextromethorphan together.

Both Paxil and dextromethorphan can increase serotonin levels in the body and have the potential of causing serotonin syndrome, a rare, but nonetheless serious condition.

Serotonin syndrome is characterized by the rapid development of hyperthermia, high blood pressure, and mental status changes.​​​ Again, serotonin syndrome is rare, but the risk increases when taking multiple serotonergic drugs. Be sure to talk to your doctor before combining Paxil and anything containing dextromethorphan.

Final Words

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