Zoloft With Unisom Interaction Details

Quick Answer

Unisom is a brand name product, and there are several different formulations containing different active ingredients (e.g., Unisom SleepGels contain diphenhydramine while Unisom SleepTabs contain doxylamine). Zoloft doesn't specifically interact with either of these Unisom products but there is a risk of certain additive side effects (e.g., drowsiness, dizziness).

Detailed Answer

As mentioned, there are several different 'Unisom' products on the market.

Although there are 'drug-free' Unisom products, when Unisom is brought up in the context of a drug interaction question like this, generally what is being referred to are the Unisom products that contain one of two sedating antihistamines:

• Diphenhydramine
• Doxylamine

Diphenhydramine is a commonly utilized sedating antihistamine available in a number of different products, including Benadryl and Unisom SleepGels.

Doxylamine is also a sedating antihistamine and can be found in products like NyQuil and Unisom SleepTabs.

Regardless of which Unisom product you are referring to, we are looking for an interaction between a sedating antihistamine and Zoloft (sertraline). You mentioned specifically the 'SleepGels', which contain diphenhydramine (the same antihistamine that is in Benadryl).

The good news here is that there is no specific interaction between Zoloft and Unisom SleepGels. Unisom does not affect the metabolism or clinical effects of Zoloft in any way.

However, and this is important to note, some common side effects of Zoloft include drowsiness and dizziness.

Since Unisom products are sedating, there is a risk of additive side effects when taken with Zoloft (e.g., additive sedative effects).

This generally isn't much of a concern since Unisom is intended for evening dosing to help sleep at night. Regardless, risk of additive sedation is important to be aware of.

Final Words

I hope you found this helpful!

Unisom and Zoloft can certainly be used together safely, just watch out for the potential of additive sedative effects, especially if Zoloft already makes you feel tired.

Reach back out anytime!