1,3-dmaa - Guaifenesin, Phenylpropanolamine Interaction
Herbal: 1,3-dmaa
Also Known As: DMAA, Dimethylamylamine
Drug: Guaifenesin, Phenylpropanolamine
Brand names:
Entex LA, Miraphen PE, Dura-Vent, Guaifed, Guaifed-PD, Guaipax SR, Banex LA
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
Jul 22, 2023
Interaction Details
Guaifenesin, Phenylpropanolamine is classified as belonging to the following category: Stimulant Drugs
1,3-DMAA is thought to have stimulant effects. There is concern that taking 1,3-DMAA with stimulant drugs might increase the risk of adverse cardiovascular effects. Some preliminary research shows that taking 1,3-DMAA 50 mg daily in combination with caffeine 250 mg daily does not increase respiratory rate, blood pressure, or other cardiovascular outcomes compared to taking caffeine alone in healthy men. However, a number of cardiovascular side effects have been reported for patients taking 1,3-DMAA in combination with other stimulants including caffeine. Theoretically, combining 1,3-DMAA with stimulant drugs might increase the risk of adverse cardiovascular effects. Some stimulant drugs include amphetamine, caffeine, diethylpropion (Tenuate), methylphenidate, phentermine (Ionamin), pseudoephedrine (Sudafed, others), and many others.
Interaction Rating
Likelihood of Occurrence
PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
References
- Adverse Event Report. Jack3d. Natural MedWatch, May 28, 2011.
- Smith TB, Staub BA, Natarajan GM, et al. Acute myocardial infarction associated with dietary supplements containing 1,3-dimethylamylamine and Citrus aurantium. Tex Heart Inst J 2014;41(1):70-2.
- Armstrong M. Atrial Fibrillation with Rapid Ventricular Response following use of Dietary Supplement Containing 1,3 Dimethylamylamine and Caffeine. J Spec Oper Med. 2012 Winter;12(4):1-4.
- Bloomer RJ, Farney TM, Harvey IC, Alleman RJ. Safety profile of caffeine and 1,3-dimethylamylamine supplementation in healthy men. Hum Exp Toxicol. 2013 Nov;32(11):1126-36.
- Brown JA, Buckley NA. Toxicity from bodybuilding supplements and recreational use of products containing 1,3-dimethylamylamine. Med J Aust. 2013 May 6;198(8):414-5.
- Dolan SB, Gatch MB. Abuse liability of the dietary supplement dimethylamylamine. Drug Alcohol Depend. 2015 Jan 1;146:97-102.
- Forrester M. Exposures to 1,3-dimethylamylamine-containing products reported to Texas poison centers. Hum Exp Toxicol. 2013 Jan;32(1):18-23.
- Van Hout MC, Hearne E. "Plant or poison": A netnographic study of recreational use of 1,3-dimethylamylamine (DMAA). Int J Drug Policy. 2015 Dec;26(12):1279-81.
1,3-dmaa Overview
1,3-Dimethylamylamine (DMAA) is a synthetic compound that was once used in dietary supplements, primarily for its purported stimulant effects. It was marketed as a performance-enhancing and weight-loss aid due to its similarities to amphetamines. However, DMAA has been banned or restricted in several countries due to safety concerns, including reports of adverse effects such as increased blood pressure, heart rate, and potential links to serious health issues like strokes and heart attacks. As a result, DMAA is no longer commonly found in legal dietary supplements.
1,3-dmaa - More Interactions
1,3-dmaa interacts with 318 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
| Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
| Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
| Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
| Unknown | No interactions have been reported or no interaction data is currently available. |
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.
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Dr. Brian Staiger, PharmD
In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!
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