African Wild Potato - Medroxyprogesterone Acetate, Oestrogens, Conjugated Interaction
Herbal: African Wild Potato
Drug: Medroxyprogesterone Acetate, Oestrogens, Conjugated
Brand names: Premique
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated Jul 22, 2023
Medroxyprogesterone Acetate, Oestrogens, Conjugated is classified as belonging to the following category: Cytochrome P450 3A4 (Cyp3A4) Substrates
In vitro evidence shows that African wild potato extract can inhibit cytochrome P450 3A4 (CYP3A4) enzyme activity by up to 86%. Theoretically, African wild potato might increase levels of drugs metabolized by CYP3A4. However, in human research, African wild potato does not seem to affect the pharmacokinetics of Efavirenz, a CYP3A4 substrate. Until more is known, use African wild potato cautiously or avoid in patients taking drugs metabolized by CYP3A4. Some drugs metabolized by CYP3A4 include lovastatin (Mevacor), ketoconazole (Nizoral), itraconazole (Sporanox), fexofenadine (Allegra), triazolam (Halcion), and numerous others.
Likelihood of OccurrencePossible
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
- Jalloh MA, Gregory PJ, Hein D, et al. Dietary supplement interactions with antiretrovirals: a systematic review. Int J STD AIDS. 2017 Jan;28(1):4-15.
African Wild Potato - More Interactions
African Wild Potato interacts with 954 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
|Major||The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur.|
|Moderate||Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur.|
|Minor||Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction.|
|Unknown||No interactions have been reported or no interaction data is currently available.|
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
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Drug descriptions are provided by MedlinePlus.