Aloe - Lanoxin (Digoxin) Interaction
Herbal: Aloe
Also Known As: Aloe vera, Aloe Capensis, Aloe Gel, Aloe Latex, Aloe Leaf Gel, Aloe Perfoliata, Aloe Vera Gel, Aloes, Burn Plant, Cape Aloe, Chritkumari, Curacao Aloe, Elephant's Gall, Ghee-Kunwar, Ghi-Kuvar, Ghrita-Kumari, Indian Aloe, Kanya, Kumari, Lily of the Desert, Miracle plant
Drug: Digoxin
Brand names:
Lanoxicaps, Lanoxin, Digitek
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
May 11, 2025
Interaction Details
Digoxin is classified as belonging to the following category: Digoxin (Lanoxin)
Theoretically, aloe latex might increase the risk of adverse effects when taken with cardiac glycosides.
Overuse of aloe latex can increase the risk of adverse effects from cardiac glycoside drugs, such as digoxin, due to potassium depletion. Overuse of aloe, along with cardiac glycoside drugs, can increase the risk of toxicity.
Interaction Rating
Likelihood of Occurrence
ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
References
- Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
Aloe Overview
Aloe vera is a plant species that is native to the Arabian Peninsula, but is widely cultivated in other hot, dry climates. It is known for its thick leaves, which contain multiple components, most notably 'aloe gel' and 'aloe latex'. The plant is used in a variety of health care products, including skin care products, cosmetics, and dietary supplements.
In traditional medicine, aloe vera is used to treat a wide range of health conditions, including skin conditions, wounds, and digestive problems. It is also used to improve hair and scalp health, and as a natural remedy for constipation.
Digoxin Overview
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Digoxin is used to treat heart failure and abnormal heart rhythms (arrhythmias). It helps the heart work better and it helps control your heart rate.
Aloe - More Interactions
Aloe interacts with 457 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
| Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
| Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
| Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
| Unknown | No interactions have been reported or no interaction data is currently available. |
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.
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Dr. Brian Staiger, PharmD
In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!
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