Aloe - NeoProfen (Ibuprofen lysine) Interaction
Herbal: Aloe
Also Known As: Aloe vera, Aloe Capensis, Aloe Gel, Aloe Latex, Aloe Leaf Gel, Aloe Perfoliata, Aloe Vera Gel, Aloes, Burn Plant, Cape Aloe, Chritkumari, Curacao Aloe, Elephant's Gall, Ghee-Kunwar, Ghi-Kuvar, Ghrita-Kumari, Indian Aloe, Kanya, Kumari, Lily of the Desert, Miracle plant
Drug: Ibuprofen lysine
Brand names:
NeoProfen
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
May 25, 2025
Interaction Details
Ibuprofen lysine is classified as belonging to the following category: Anticoagulant/Antiplatelet Drugs
Theoretically, aloe gel might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
In vitro research shows that aloe gel can inhibit platelet aggregation. This inhibition was greater than that seen with celecoxib, but less than that seen with aspirin.
Interaction Rating
Likelihood of Occurrence
PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
References
- Mushtaq S, Mushtaq Z, Sarfraz J, et al. Comparison of effect of aloe vera gel with aspirin and celecoxib on platelet aggregation. Professional Med J. 2020; 27(5):973-978.
Aloe Overview
Aloe vera is a plant species that is native to the Arabian Peninsula, but is widely cultivated in other hot, dry climates. It is known for its thick leaves, which contain multiple components, most notably 'aloe gel' and 'aloe latex'. The plant is used in a variety of health care products, including skin care products, cosmetics, and dietary supplements.
In traditional medicine, aloe vera is used to treat a wide range of health conditions, including skin conditions, wounds, and digestive problems. It is also used to improve hair and scalp health, and as a natural remedy for constipation.
Ibuprofen lysine Overview
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Prescription ibuprofen is used to relieve pain, tenderness, swelling, and stiffness caused by osteoarthritis (arthritis caused by a breakdown of the lining of the joints) and rheumatoid arthritis (arthritis caused by swelling of the lining of the joints). It is also used to relieve mild to moderate pain, including menstrual pain (pain that happens before or during a menstrual period). Nonprescription ibuprofen is used to reduce fever and to relieve minor aches and pain from headaches, muscle aches, arthritis, menstrual periods, the common cold, toothaches, and backaches. Ibuprofen is in a class of medications called NSAIDs. It works by stopping the body's production of a substance that causes pain, fever, and inflammation.
Aloe - More Interactions
Aloe interacts with 457 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
| Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
| Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
| Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
| Unknown | No interactions have been reported or no interaction data is currently available. |
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.
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Dr. Brian Staiger, PharmD
In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!
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