Olive Oil - Metolazone Interaction
Herbal: Olive Oil
Drug: Metolazone
Brand names:
Diulo, Zaroxolyn, Mykrox
![](https://hellopharmacist.nyc3.digitaloceanspaces.com/images/OBrXo3ni0aNq6p1xr8LXWNogoaVtCExyhTj9MEzw.jpg)
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
May 26, 2024
Interaction Details
Metolazone is classified as belonging to the following category: Antihypertensive Drugs
Theoretically, taking olive oil with antihypertensive drugs might have additive effects on blood pressure.
Some clinical and observational research suggests that adding olive oil into the diet, especially in place of saturated fat, is associated with reduced blood pressure.
Interaction Rating
Likelihood of Occurrence
ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
Pharmacist Analysis
There are some indications that consuming olive oil with antihypertensive medication may have an additive effect on lowering blood pressure.
Clinical and observational research has shown that adding olive oil to the diet, especially in place of saturated fats, is associated with reduced blood pressure.
In one study, the consumption of olive oil and vegetable oil was inversely associated with serum cholesterol and glucose levels and systolic blood pressure. These findings suggest that monounsaturated fats like olive oil may be associated with a lower risk of cardiovascular disease.
Another study found that death rates from all causes, including coronary heart disease, were low in populations that consumed olive oil as the main fat. Although causal relationships are not claimed, these findings suggest that the monounsaturated fatty acids found in olive oil, particularly oleic acid, may have protective effects on heart health.
While olive oil is generally not known to lower blood pressure too low (i.e., cause hypotension), it's important to monitor blood pressure levels regularly and consult with a healthcare provider if there are any concerns. It is also possible that dose adjustments may be necessary under a doctor's supervision.
References
- Trevisan M, Krogh V, Freudenheim J, et al. Consumption of olive oil, butter, and vegetable oils and coronary heart disease risk factors. The Research Group ATS-RF2 of the Italian National Research Council. JAMA 1990;263:688-92.
- Keys A, Menotti A, Karvonen MJ , et al. The diet and 15-year death rate in the seven countries study. Am J Epidemiol 1986;124:903-15.
- Ferrara LA, Raimondi AS, d'Episcopo L, et al. Olive oil and reduced need for antihypertensive medications. Arch Intern Med 2000;160:837-42.
Olive Oil Overview
![Olive Oil](https://hellopharmacist.nyc3.digitaloceanspaces.com/images/herbals/width_250/Fh4aDS85wVEzex1Nc1wzTm35PzSqus2iQ6FcMbhP.jpg)
Metolazone Overview
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Metolazone, is used to reduce the swelling and fluid retention caused by heart failure or kidney disease. It also is used alone or with other medications to treat high blood pressure. Metolazone is in a class of medications called diuretics ('water pills'). It causes the kidneys to reduce the amount of water and salt in the body by increasing the amount of urine.
Olive Oil - More Interactions
Olive Oil interacts with 169 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
Unknown | No interactions have been reported or no interaction data is currently available. |
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.