Abatacept Injection and Typhoid Vaccine, Live: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Jul 10, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Abatacept Injection
Typhoid Vaccine, Live
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Secondary transmission of infection by the live vaccine; reduced effectiveness of immunization
Interaction Deep Dive
Although no data are available regarding the effects of vaccination in patients receiving abatacept therapy, the administration of live vaccines during or within 3 months following abatacept treatment is not recommended. The possibility exists for abatacept to affect host defenses against infections since the cellular immune response may be altered. As a result, abatacept may reduce the efficacy of the vaccine. There is no data regarding the secondary transmission of infection from those receiving live vaccines to patients treated with abatacept1.
Why it happens (mechanism)
Altered cellular immune response
Common questions
Can I take Abatacept Injection and Typhoid Vaccine, Live together?
Secondary transmission of infection by the live vaccine; reduced effectiveness of immunization Always confirm with your pharmacist or prescriber before making any change.
How serious is the Abatacept Injection and Typhoid Vaccine, Live interaction?
It is rated moderate. Can be significant — usually manageable with monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "probable". Good supporting evidence, though not definitively proven.
Questions for your pharmacist
- Does my dose of Abatacept Injection or Typhoid Vaccine, Live need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there anything you'd monitor while I'm on both?
References (1)
- Product Information: ORENCIA(R) IV powder, abatacept IV powder. Bristol-Myers Squibb, Princeton, NJ, 2008.
Keep reading about Abatacept Injection
Keep reading about Typhoid Vaccine, Live
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