Acebutolol

188 interactions 1 explained in plain English 508 cited references

Also sold as: Sectral®

About Acebutolol

Acebutolol is used to treat high blood pressure. Acebutolol also is used to treat an irregular heartbeat. Acebutolol is in a class of medications called beta blockers. It works by relaxing blood vessels and slowing heart rate to improve blood flow and decrease blood pressure. High blood pressure is a common condition a… Read the full Acebutolol drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 16, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Albuterol Oral Inhalation Olodaterol Oral Inhalation Vilanterol Verapamil Terbutaline Taletrectinib

35 Major 153 Moderate

All (188) Major (35) Moderate (153)

Moderate

Acebutolol Methyldopa Aldomet® Exaggerated hypertensive response, tachycardia, or arrhythmias during physiologic stress or exposure to exogenous catecholamines Details Acebutolol Metildigoxin Increased risk of bradycardia and possible digitalis glycoside toxicity Details Acebutolol Miglitol Glyset® Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Acebutolol Morniflumate Reduced antihypertensive effect Details Acebutolol Moxisylyte An exaggerated hypotensive response to the first dose of the alpha blocker Details Acebutolol Moxonidine Rebound hypertension Details Acebutolol Nabumetone Relafen Reduced antihypertensive effect Details Acebutolol Naproxen Aleve Reduced antihypertensive effect Details Acebutolol Nateglinide Starlix® Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Acebutolol Nepafenac Ilevro Reduced antihypertensive effect Details Acebutolol Nifedipine Adalat® An increased risk of congestive heart failure, severe hypotension or exacerbation of angina Details Acebutolol Niflumic Acid Reduced antihypertensive effect Details Acebutolol Nimesulide Reduced antihypertensive effect Details Acebutolol Nimesulide Beta Cyclodextrin Reduced antihypertensive effect Details Acebutolol Oxaprozin Coxanto Reduced antihypertensive effect Details Acebutolol Oxyphenbutazone Reduced antihypertensive effect Details Acebutolol Paltusotine Palsonify An increased risk of PR interval prolongation Details Acebutolol Parecoxib Reduced antihypertensive effect Details Acebutolol Phenoxybenzamine Dibenzyline An exaggerated hypotensive response to the first dose of the alpha blocker Details Acebutolol Phentolamine An exaggerated hypotensive response to the first dose of the alpha blocker Details Acebutolol Phenylbutazone Equi-Phar Reduced antihypertensive effect Details Acebutolol Piketoprofen Reduced antihypertensive effect Details Acebutolol Pioglitazone Actos Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Acebutolol Piroxicam Feldene Reduced antihypertensive effect Details Acebutolol Pramlintide Symlin Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Acebutolol Pranoprofen Reduced antihypertensive effect Details Acebutolol Prazosin Minipress An exaggerated hypotensive response to the first dose of the alpha blocker Details Acebutolol Proglumetacin Reduced antihypertensive effect Details Acebutolol Propyphenazone Reduced antihypertensive effect Details Acebutolol Proquazone Reduced antihypertensive effect Details Acebutolol Repaglinide Prandin® Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Acebutolol Rofecoxib Reduced antihypertensive effect Details Acebutolol Rosiglitazone Avandia® Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Acebutolol Salicylic Acid Reduced antihypertensive effect Details Acebutolol Salsalate Disalcid Reduced antihypertensive effect Details Acebutolol Saxagliptin Onglyza Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Acebutolol Sitagliptin Brynovin Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Acebutolol Sodium Salicylate Reduced antihypertensive effect Details Acebutolol Sulindac Clinoril® Reduced antihypertensive effect Details Acebutolol Tamsulosin Flomax An exaggerated hypotensive response to the first dose of the alpha blocker Details

Check another drug

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist

Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.