Acebutolol

188 interactions 1 explained in plain English 508 cited references

Also sold as: Sectral®

About Acebutolol

Acebutolol is used to treat high blood pressure. Acebutolol also is used to treat an irregular heartbeat. Acebutolol is in a class of medications called beta blockers. It works by relaxing blood vessels and slowing heart rate to improve blood flow and decrease blood pressure. High blood pressure is a common condition a… Read the full Acebutolol drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 16, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Albuterol Oral Inhalation Olodaterol Oral Inhalation Vilanterol Verapamil Terbutaline Taletrectinib

35 Major 153 Moderate

All (188) Major (35) Moderate (153)

Moderate

Acebutolol Tenoxicam Reduced antihypertensive effect Details Acebutolol Terazosin Hytrin® An exaggerated hypotensive response to the first dose of the alpha blocker Details Acebutolol Tiaprofenic Acid Reduced antihypertensive effect Details Acebutolol Tolazamide Tolinase® Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Acebutolol Tolbutamide Orinase® Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Acebutolol Tolfenamic Acid Reduced antihypertensive effect Details Acebutolol Tolmetin Tolectin 600 Reduced antihypertensive effect Details Acebutolol Tranylcypromine Parnate An increased risk of more pronounced bradycardia and postural hypotension Details Acebutolol Trimazosin An exaggerated hypotensive response to the first dose of the alpha blocker Details Acebutolol Urapidil An exaggerated hypotensive response to the first dose of the alpha blocker Details Acebutolol Valdecoxib Reduced antihypertensive effect Details Acebutolol Vildagliptin Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Acebutolol Yohimbine Reduced beta-adrenergic blocker effectiveness Details Acebutolol Bromfenac Ophthalmic Bromday® Reduced antihypertensive effect Details Acebutolol Diclofenac Ophthalmic Voltaren® Eye Drops Reduced antihypertensive effect Details Acebutolol Diclofenac Topical (Actinic Keratosis) Pennsaid Reduced antihypertensive effect Details Acebutolol Diclofenac Topical (Arthritis Pain) Pennsaid® Reduced antihypertensive effect Details Acebutolol Diclofenac Transdermal Patch Flector Reduced antihypertensive effect Details Acebutolol Dulaglutide Injection Trulicity Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Acebutolol Exenatide Injection Bydureon Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Acebutolol Flurbiprofen Ophthalmic Ocufen Reduced antihypertensive effect Details Acebutolol Glucagon Injection Baqsimi A transient increase in pulse and blood pressure Details Acebutolol Glucagon Injection / Solution Baqsimi A transient increase in pulse and blood pressure Details Acebutolol Glucagon Nasal Powder Baqsimi A transient increase in pulse and blood pressure Details Acebutolol Insulin Degludec (Rdna Origin) Injection Ryzodeg® (as a combination product containing Insulin Degludec and Insulin Aspart) Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Acebutolol Insulin Detemir (Rdna Origin) Injection Levemir Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Acebutolol Insulin Glulisine (Rdna Origin) Injection Apidra Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Acebutolol Ketorolac Injection Acular Reduced antihypertensive effect Details Acebutolol Ketorolac Nasal Spray Sprix Reduced antihypertensive effect Details Acebutolol Ketorolac Ophthalmic Acular Reduced antihypertensive effect Details Acebutolol Liraglutide Injection Saxenda Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Acebutolol Lixisenatide Injection Adlyxin® Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Acebutolol Meloxicam Injection Alloxate Reduced antihypertensive effect Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.