Alfentanil
100 interactions 7 explained in plain English
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
· Updated Jul 4, 2026
· Editorial policy
· Data sources
Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →
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Major
Alfentanil Acetaminophen And Codeine Capital® & Codeine Explained Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Alfentanil Amitriptyline Elavil Explained An increased risk of serotonin syndrome and an increased risk of paralytic ileus Details Alfentanil Sertraline Explained Increased risk of serotonin syndrome Details Alfentanil Buprenorphine Belbuca Explained An increased risk of CNS depression, profound sedation, respiratory depression, hypotension, coma and death, reduced analgesic eff... Details Alfentanil Relugolix Orgovyx Explained Reduced ALfentanil exposure, reduced efficacy of ALfentanil and an increased risk of a withdrawal syndrome Details Alfentanil Trospium / Xanomeline Cobenfy Explained An increased risk of urinary retention and/or severe constipation, which may lead to paralytic ileus Details Alfentanil Aripiprazole Injection Abilify Increased risk of respiratory or CNS depression and hypotension Details Alfentanil Asciminib Scemblix Increased CYP3A4 exposure and an increased risk of CYP3A4-related adverse reactions Details Alfentanil Asenapine Transdermal Patch Secuado Increased risk of respiratory or CNS depression and hypotension Details Alfentanil Azithromycin AzaSite Increased ALfentanil exposure and an increased risk of respiratory depression Details Alfentanil Belumosudil Rezurock Explained Increased ALfentanil exposure and an increased risk of respiratory depression Details Alfentanil Bicalutamide Casodex Increased ALfentanil exposure and an increased risk of respiratory depression Details Alfentanil Atorvastatin Atorvaliq Increased ALfentanil exposure and an increased risk of respiratory depression Details Alfentanil Aclidinium Oral Inhalation Tudorza An increased risk of urinary retention and/or severe constipation, which may lead to paralytic ileus Details Alfentanil Amlodipine Amvaz® Increased ALfentanil exposure and an increased risk of respiratory depression Details Alfentanil Atropine Ophthalmic Atropine Care 1% An increased risk of urinary retention and/or severe constipation, which may lead to paralytic ileus Details Alfentanil Bexarotene Targretin Reduced ALfentanil exposure, reduced efficacy of ALfentanil and an increased risk of a withdrawal syndrome Details Alfentanil Bexarotene Topical Targretin Reduced ALfentanil exposure, reduced efficacy of ALfentanil and an increased risk of a withdrawal syndrome Details Alfentanil Brigatinib Alunbrig Reduced ALfentanil exposure, reduced efficacy of ALfentanil and an increased risk of a withdrawal syndrome Details Alfentanil Brivaracetam Briviact Reduced ALfentanil exposure, reduced efficacy of ALfentanil and an increased risk of a withdrawal syndrome Details Alfentanil Brivaracetam Injection Briviact Reduced ALfentanil exposure, reduced efficacy of ALfentanil and an increased risk of a withdrawal syndrome Details Alfentanil Brodalumab Injection Siliq Increased ALfentanil exposure and an increased risk of respiratory depression Details Alfentanil Butorphanol Injection Butorphic An increased risk of CNS depression, profound sedation, respiratory depression, hypotension, coma and death, reduced analgesic eff... Details Alfentanil Butorphanol Nasal Spray Stadol® NS An increased risk of CNS depression, profound sedation, respiratory depression, hypotension, coma and death, reduced analgesic eff... Details Alfentanil Cetirizine Injection Aller-Tec Increased risk of CNS depression Details Alfentanil Cetirizine Ophthalmic Zerviate Increased risk of CNS depression Details Alfentanil Clopidogrel Plavix Reduced efficacy of clopidogrel Details Alfentanil Clotrimazole Aardora Anti-Fungal Maximum Strength Increased ALfentanil exposure and an increased risk of respiratory depression Details Alfentanil Clotrimazole Lozenge Mycelex® Increased ALfentanil exposure and an increased risk of respiratory depression Details Alfentanil Clotrimazole Topical Cruex Antifungal Increased ALfentanil exposure and an increased risk of respiratory depression Details Alfentanil Clotrimazole Vaginal Gyne-Lotrimin 3® Cream Increased ALfentanil exposure and an increased risk of respiratory depression Details Alfentanil Cyclopentolate Ophthalmic Akpentolate® An increased risk of urinary retention and/or severe constipation, which may lead to paralytic ileus Details Alfentanil Cyclosporine Injection Atopica Increased ALfentanil exposure and an increased risk of respiratory depression Details Alfentanil Cyclosporine Ophthalmic Cequa Increased ALfentanil exposure and an increased risk of respiratory depression Details Alfentanil Darolutamide Nubeqa Reduced ALfentanil exposure, reduced efficacy of ALfentanil and an increased risk of a withdrawal syndrome Details Alfentanil Dexamethasone Injection Decadron Reduced ALfentanil exposure, reduced efficacy of ALfentanil and an increased risk of a withdrawal syndrome Details Alfentanil Dexamethasone Ophthalmic Dexacidin® (as a combination product containing Dexamethasone, Neomycin, Polymyxin B) Reduced ALfentanil exposure, reduced efficacy of ALfentanil and an increased risk of a withdrawal syndrome Details Alfentanil Diazepam Nasal Spray Valtoco Increased risk of respiratory or CNS depression and hypotension Details Alfentanil Diazepam Rectal Diastat Increased risk of respiratory or CNS depression and hypotension Details Alfentanil Diphenhydramine Injection Banophen An increased risk of respiratory and CNS depression and an increased risk of paralytic ileus DetailsNo interactions on this page match that filter — try the next page or clear the filter.
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