Alfentanil

100 interactions 7 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Acetaminophen And Codeine Bicalutamide Palonosetron Injection Brivaracetam Injection Olaparib Trospium / Xanomeline
97 Major 3 Moderate
All (100) Major (97) Moderate (3)

Major

Alfentanil Lurasidone Latuda Increased ALfentanil exposure and an increased risk of respiratory depression Details Alfentanil Medroxyprogesterone Amen® Increased ALfentanil exposure, an increased risk of ALfentanil-related adverse reactions and/or prolonged effects, which may exace... Details Alfentanil Medroxyprogesterone Injection Depo-Provera Increased ALfentanil exposure, an increased risk of ALfentanil-related adverse reactions and/or prolonged effects, which may exace... Details Alfentanil Metoclopramide Injection Gimoti Increased risk of CNS depression Details Alfentanil Metoclopramide Nasal Spray Gimoti Increased risk of CNS depression Details Alfentanil Midazolam Nasal Spray Nayzilam Increased risk of respiratory or CNS depression and hypotension Details Alfentanil Midazolam Injection Nayzilam Increased risk of respiratory or CNS depression and hypotension Details Alfentanil Mitapivat Aqvesme Reduced CYP3A substrate exposure Details Alfentanil Morphine Injection Astramorph® PF Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Alfentanil Nafcillin Injection Unipen® Injection Reduced ALfentanil exposure, reduced efficacy of ALfentanil and an increased risk of a withdrawal syndrome Details Alfentanil Nalbuphine Injection Nubain® An increased risk of CNS depression, profound sedation, respiratory depression, hypotension, coma and death, reduced analgesic eff... Details Alfentanil Nevirapine Viramune Reduced ALfentanil exposure, reduced efficacy of ALfentanil and an increased risk of a withdrawal syndrome Details Alfentanil Octreotide Bynfezia Increased exposure of CYP3A4 substrates with narrow therapeutic index Details Alfentanil Octreotide Injection Bynfezia Increased exposure of CYP3A4 substrates with narrow therapeutic index Details Alfentanil Olaparib Lynparza Increased ALfentanil exposure and an increased risk of respiratory depression Details Alfentanil Olutasidenib Rezlidhia Reduced sensitive CYP3A substrate exposure Details Alfentanil Palonosetron Injection Aloxi® Increased risk of serotonin syndrome Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.