Amphotericin B Lipid Complex and Cyclosporine Ophthalmic: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Cyclosporine Ophthalmic
Amphotericin B Lipid Complex
No brand names on record
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
An increased risk of cycloSPORINE toxicity (renal dysfunction, cholestasis, paresthesias)
Interaction Deep Dive
Reports have described an increase in the cycloSPORINE level when amphotericin B lipid complex is coadministered. However, the cycloSPORINE level seems to decrease to approximately 1.5 times its previous value with the continuation of amphotericin B lipid complex1.
Why it happens (mechanism)
Additive or synergistic nephrotoxicity
Literature reports
1 report — tap to read
a) A 50-year-old male with a cadaveric renal transplant experienced an increase in his cycloSPORINE level when amphotericin B lipid complex (Abelcet(R)) was added to therapy for an Apophysomyces elegans infection. Other medications included prednisone, azathioprine, clotrimazole, and insulin. Treatment for his arm ulcer caused by a bicycle accident was initiated with vancomycin, ceftazidime, and amphotericin B. In an attempt to preserve the patient's renal function, the antifungal therapy was switched to amphotericin B lipid complex on the sixth hospital day. The cycloSPORINE level more than doubled in the four days following the initiation of amphotericin B lipid complex, and then returned to levels about 1.5 times the pretreatment levels. Because the cycloSPORINE concentration returned to near normal with the continuation of amphotericin B lipid complex therapy is suggestive of a drug displacement interaction with a slow clearance change to compensate for the higher cycloSPORINE concentrations 1.
Common questions
Can I take Amphotericin B Lipid Complex and Cyclosporine Ophthalmic together?
An increased risk of cycloSPORINE toxicity (renal dysfunction, cholestasis, paresthesias) Always confirm with your pharmacist or prescriber before making any change.
How serious is the Amphotericin B Lipid Complex and Cyclosporine Ophthalmic interaction?
It is rated moderate. Can be significant — usually manageable with monitoring.
How quickly could this interaction happen?
The documented onset is "delayed". Effects tend to build up gradually over days to weeks.
How strong is the evidence for this interaction?
The evidence is graded "probable". Good supporting evidence, though not definitively proven.
Questions for your pharmacist
- Does my dose of Amphotericin B Lipid Complex or Cyclosporine Ophthalmic need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there anything you'd monitor while I'm on both?
References (1)
- Naguib MT, Huycke MM, Pederson JA, et al: Apophysomyces elegans infection in a renal transplant recipient. Am J Kidney Dis 1995; 26:381-384. PubMed
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