Amtolmetin Guacil

87 interactions 5 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ketorolac Nasal Spray Ketorolac Ophthalmic Ketorolac Ketorolac Injection Pemetrexed Injection Melphalan
4 Contraindicated 55 Major 28 Moderate
All (87) Contraindicated (4) Major (55) Moderate (28)

Major

Amtolmetin Guacil Ketoprofen Actron® Increased risk of bleeding Details Amtolmetin Guacil Lithium Carbonate Lithobid Increased lithium exposure and an increased risk of lithium toxicity Details Amtolmetin Guacil Meclofenamate Meclodium® Increased risk of bleeding Details Amtolmetin Guacil Mefenamic Acid Ponstel® Increased risk of bleeding Details Amtolmetin Guacil Meloxicam Alloxate Increased risk of bleeding Details Amtolmetin Guacil Meloxicam Injection Alloxate Increased risk of bleeding Details Amtolmetin Guacil Melphalan Alkeran An increased risk of bleeding Details Amtolmetin Guacil Melphalan Injection Alkeran An increased risk of bleeding Details Amtolmetin Guacil Mesalamine Apriso Increased risk of bleeding Details Amtolmetin Guacil Mesalamine Rectal Canasa Increased risk of bleeding Details Amtolmetin Guacil Methotrexate Jylamvo Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Amtolmetin Guacil Methotrexate Injection Abitrexate® Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Amtolmetin Guacil Nabumetone Relafen Increased risk of bleeding Details Amtolmetin Guacil Naproxen Aleve Increased risk of bleeding Details Amtolmetin Guacil Pemetrexed Injection Alimta Increased PEMEtrexed exposure and an increased risk of PEMEtrexed toxicity (myelosuppression, renal toxicity, and gastrointestinal... Details

Check another drug

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist
Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.