Argatroban

56 interactions 2 explained in plain English

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Defibrotide Injection Dipyridamole Orlistat Naproxen Heparin Omadacycline

1 Contraindicated 51 Major 4 Moderate

All (56) Contraindicated (1) Major (51) Moderate (4)

Contraindicated

Argatroban Defibrotide Injection Defitelio Increased risk of bleeding Details

Major

Argatroban Sertraline Explained An increased risk of bleeding Details Argatroban Apixaban Eliquis Explained An increased risk of bleeding and can cause serious, potentially fatal bleeding Details Argatroban Aspirin Acuprin® Increased risk of bleeding Details Argatroban Aspirin Rectal Aspirin Increased risk of bleeding Details Argatroban Betrixaban Bevyxxa® Increased risk of bleeding Details Argatroban Anagrelide Agrylin Increased risk of bleeding Details Argatroban Bromfenac Ophthalmic Bromday® An increased risk of bleeding Details Argatroban Caplacizumab-Yhdp Injection Cablivi An increased risk of bleeding Details Argatroban Clopidogrel Plavix Increased risk of bleeding Details Argatroban Dabigatran Pradaxa® An increased risk of bleeding Details Argatroban Dabigatran Etexilate An increased risk of bleeding Details Argatroban Dalteparin Injection Fragmin Increased risk of bleeding Details Argatroban Diclofenac Ophthalmic Voltaren® Eye Drops An increased risk of bleeding Details Argatroban Diclofenac Topical (Actinic Keratosis) Pennsaid An increased risk of bleeding Details Argatroban Diclofenac Topical (Arthritis Pain) Pennsaid® An increased risk of bleeding Details Argatroban Diclofenac Transdermal Patch Flector An increased risk of bleeding Details Argatroban Dipyridamole Permole® Increased risk of bleeding Details Argatroban Doxycycline Injection Acticlate An increased risk of bleeding Details Argatroban Edoxaban Savaysa Increased risk of bleeding Details Argatroban Enoxaparin Lovenox Increased risk of bleeding Details Argatroban Enoxaparin Injection Lovenox Increased risk of bleeding Details Argatroban Epoprostenol Flolan Increased risk of bleeding Details Argatroban Etodolac Lodine An increased risk of bleeding Details Argatroban Fenoprofen Fenopron An increased risk of bleeding Details Argatroban Flurbiprofen Ansaid An increased risk of bleeding Details Argatroban Flurbiprofen Ophthalmic Ocufen An increased risk of bleeding Details Argatroban Fondaparinux Arixtra Increased risk of bleeding Details Argatroban Fondaparinux Injection Arixtra Increased risk of bleeding Details Argatroban Heparin Increased risk of bleeding Details Argatroban Heparin Injection Lipo-Hepin® Increased risk of bleeding Details Argatroban Ibrutinib Imbruvica Increased risk of bleeding Details Argatroban Ibuprofen Addaprin An increased risk of bleeding Details Argatroban Iloprost Aurlumyn Increased risk of bleeding Details Argatroban Ketoprofen Actron® An increased risk of bleeding Details Argatroban Ketorolac Acular An increased risk of bleeding Details Argatroban Ketorolac Injection Acular An increased risk of bleeding Details Argatroban Ketorolac Nasal Spray Sprix An increased risk of bleeding Details Argatroban Ketorolac Ophthalmic Acular An increased risk of bleeding Details Argatroban Lecanemab-Irmb Injection Leqembi An increased risk of amyloid related imaging abnormalities (ARIA), or intracerebral hemorrhage Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.