Aripiprazole Injection and Cholecalciferol: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Jul 11, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Aripiprazole Injection
Cholecalciferol
No brand names on record
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Decreased concentration of aripiprazole
Interaction Deep Dive
Coadministration of aripiprazole (CYP3A substrate) and vitamin D (CYP3A inducer) may decrease the serum concentration of aripiprazole and, therefore, decrease its efficacy. Higher vitamin D levels were associated with a greater likelihood of insufficient blood concentrations of antipsychotic drugs in a small study. In patients with schizophrenia where vitamin D supplementation is deemed clinically indicated, consider aripiprazole therapeutic drug monitoring-guided dosage adjustment to prevent worsening symptoms1.
Why it happens (mechanism)
Induction of CYP3A4-mediated metabolism of aripiprazole by vitamin D
Literature reports
1 report — tap to read
a) In a small study with 12 serum concentrations of aripiprazole, dose-adjusted serum concentrations of aripiprazole were significantly decreased with vitamin D in patients with schizophrenia (N=121; 107 antipsychotic serum concentrations evaluable; 80 serum vitamin D levels evaluable). Metabolite to parent compound ratio (MPR), a direct measure of metabolizing enzyme activity, showed a non-significant positive correlation. Among serum concentrations of quetiapine and the active moiety of aripiprazole (n=23), 11 concentrations were in patients with vitamin D levels below the median and 12 with vitamin D levels above the median; of those with concentrations below the median, 91% had drug concentrations above the lower limit of the therapeutic reference range compared with 50% among patients with vitamin D levels above the median. In summary, patients with vitamin D levels above the median had a significantly higher proportion of drug concentrations below the lower limit of the therapeutic range 1.
Common questions
Can I take Aripiprazole Injection and Cholecalciferol together?
Decreased concentration of aripiprazole Always confirm with your pharmacist or prescriber before making any change.
How serious is the Aripiprazole Injection and Cholecalciferol interaction?
It is rated moderate. Can be significant — usually manageable with monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
Questions for your pharmacist
- Does my dose of Aripiprazole Injection or Cholecalciferol need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there anything you'd monitor while I'm on both?
References (1)
- Gaebler AJ, Finner-Prevel M, Lammertz S, et al: The negative impact of vitamin D on antipsychotic drug exposure may counteract its potential benefits in schizophrenia. Br J Clin Pharmacol 2022; 88(7):3193-3200. PubMed
Keep reading about Aripiprazole Injection
Check another combination
Our instant two-drug interaction checker is almost here.
Still have questions about this combination?
Every question gets a real answer from a licensed pharmacist — free, and usually within a day.
Ask the pharmacist