Aripiprazole Injection and Nordazepam: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Jul 11, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Nordazepam
No brand names on recordAripiprazole Injection
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
An increased risk of sedation and orthostatic hypotension
Interaction Deep Dive
Concomitant administration of ARIPiprazole with benzodiazepines may intensify sedation and may increase the risk of orthostatic hypotension. Monitor sedation and blood pressure and adjust the dose accordingly1. Avoid concomitant use of ARIPiprazole with benzodiazepines because the dosage of Aristada Initio(R) cannot be modified 2.
Why it happens (mechanism)
Unknown
Literature reports
1 report — tap to read
a) The intensity of sedation was greater with the combination of oral ARIPiprazole and LORazepam as compared to that observed with ARIPiprazole alone. The orthostatic hypotension observed was greater with the combination as compared to that observed with LORazepam alone 1.
Common questions
Can I take Aripiprazole Injection and Nordazepam together?
An increased risk of sedation and orthostatic hypotension Always confirm with your pharmacist or prescriber before making any change.
How serious is the Aripiprazole Injection and Nordazepam interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
Questions for your pharmacist
- Does my dose of Aripiprazole Injection or Nordazepam need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (2)
- Product Information: ABILIFY ASIMTUFII(R) intramuscular extended-release suspension, aripiprazole intramuscular extended-release suspension. Otsuka America Pharmaceutical Inc (per FDA), Rockville, MD, 2023.
- Product Information: ARISTADA INITIO (R) intramuscular extended-release injection, aripiprazole lauroxil intramuscular extended-release injection. Alkermes, Inc (per manufacturer), Waltham, MA, 2020.
Keep reading about Nordazepam
Keep reading about Aripiprazole Injection
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