Aripiprazole Injection

347 interactions 801 cited references

Also sold as: Abilify Abilify Maintena® Abilify® Aristad Initio® Aristada® Opipza

About Aripiprazole Injection

Aripiprazole extended-release injection (Abilify Maintena, Aristada, Aristada Initio) is used alone or in combination with other aripiprazole preparations to treat schizophrenia (a mental illness that causes disturbed or unusual thinking, loss of interest in life, and strong or inappropriate emotions). Aripiprazole ext… Read the full Aripiprazole Injection drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 12, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Mavorixafor Mesoridazine Metoclopramide Pimozide Piperaquine Posaconazole

20 Contraindicated 316 Major 11 Moderate

All (347) Contraindicated (20) Major (316) Moderate (11)

Contraindicated

Aripiprazole Injection Bepridil An increased risk of QT interval prolongation Details Aripiprazole Injection Bromopride Increased risk of extrapyramidal reactions Details Aripiprazole Injection Cisapride Propulsid® Increased risk of QT interval prolongation Details Aripiprazole Injection Dronedarone Multaq Increased risk of QT interval prolongation Details Aripiprazole Injection Ensitrelvir Increased CYP3A substrates exposure and an increased risk of CYP3A substrates-related adverse effects Details Aripiprazole Injection Fluconazole Diflucan Increased ARIPiprazole or ARIPiprazole lauroxil (prodrug of ARIPiprazole) exposure and an increased risk of QT interval prolongati... Details Aripiprazole Injection Isocarboxazid Marplan An increased risk of CNS depression Details Aripiprazole Injection Ketoconazole Extina Increased ARIPiprazole exposure and an increased risk of QT interval prolongation Details Aripiprazole Injection Levoketoconazole Recorlev An increased risk of QT interval prolongation and torsades pointes, an increased CYP3A4 substrate exposure and an increased risk o... Details Aripiprazole Injection Mavorixafor Xolremdi Increased CYP2D6 substrate exposure, increased risk of CYP2D6-related adverse events and an increased risk of QT interval prolonga... Details Aripiprazole Injection Mesoridazine Increased risk of CNS depression and an increased risk of QT interval prolongation Details Aripiprazole Injection Metoclopramide An increased risk of extrapyramidal reactions and neuroleptic malignant syndrome Details Aripiprazole Injection Pimozide Increased risk of CNS depression and an increased risk of QT interval prolongation Details Aripiprazole Injection Piperaquine Increased exposure of CYP3A4 substrates and an increased risk of QT interval prolongation Details Aripiprazole Injection Posaconazole Noxafil Increased ARIPiprazole exposure and an increased risk of QT interval prolongation Details Aripiprazole Injection Saquinavir An increased risk of QT interval prolongation Details Aripiprazole Injection Sparfloxacin An increased risk of QT interval prolongation Details Aripiprazole Injection Terfenadine An increased risk of QT interval prolongation Details Aripiprazole Injection Thioridazine An increased risk of QT interval prolongation Details Aripiprazole Injection Ziprasidone Geodon An increased risk of QT interval prolongation and an increased risk of CNS depression Details

Major

Aripiprazole Injection Abametapir Increased exposure of CYP3A4 substrate Details Aripiprazole Injection Abiraterone Acetate Abirtega Increased CYP2D6 substrate exposure and an increased risk of CYP2D6 substrate-related adverse effects Details Aripiprazole Injection Abiraterone Acetate, Micronized Abirtega Increased CYP2D6 substrate exposure and an increased risk of CYP2D6 substrate-related adverse effects Details Aripiprazole Injection Adagrasib Krazati Increased ARIPiprazole exposure and an increased risk of QT interval prolongation Details Aripiprazole Injection Alfentanil Increased risk of respiratory or CNS depression and hypotension Details Aripiprazole Injection Alfuzosin UroXatral An increased risk of QT interval prolongation Details Aripiprazole Injection Alprazolam Xanax Increased risk of CNS depression Details Aripiprazole Injection Amiodarone Nexterone An increased risk of QT interval prolongation and torsade de pointes Details Aripiprazole Injection Amisulpride Barhemsys Increased risk of serious ventricular arrhythmias such as torsades de pointes Details Aripiprazole Injection Amitriptyline Elavil An increased risk of QT interval prolongation Details Aripiprazole Injection Anagrelide Agrylin An increased risk of QT interval prolongation Details Aripiprazole Injection Apalutamide Erleada Reduced ARIPiprazole exposure Details Aripiprazole Injection Apomorphine Apokyn An increased risk of QT interval prolongation Details Aripiprazole Injection Arsenic Trioxide Trisenox An increased risk of QT interval prolongation Details Aripiprazole Injection Artemether An increased risk of QT interval prolongation, reduced CYP3A4 substrates exposure and reduced efficacy of CYP3A4 substrates Details Aripiprazole Injection Asenapine Saphris An increased risk of QT interval prolongation Details Aripiprazole Injection Astemizole An increased risk of QT interval prolongation Details Aripiprazole Injection Atazanavir Reyataz An increased risk of QT interval prolongation Details Aripiprazole Injection Avacopan Tavneos Increased CYP3A4 substrate exposure Details Aripiprazole Injection Azithromycin AzaSite An increased risk of QT interval prolongation Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.