Aripiprazole Injection

347 interactions 801 cited references

Also sold as: Abilify Abilify Maintena® Abilify® Aristad Initio® Aristada® Opipza

About Aripiprazole Injection

Aripiprazole extended-release injection (Abilify Maintena, Aristada, Aristada Initio) is used alone or in combination with other aripiprazole preparations to treat schizophrenia (a mental illness that causes disturbed or unusual thinking, loss of interest in life, and strong or inappropriate emotions). Aripiprazole ext… Read the full Aripiprazole Injection drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 12, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Mavorixafor Mesoridazine Metoclopramide Pimozide Piperaquine Posaconazole

20 Contraindicated 316 Major 11 Moderate

All (347) Contraindicated (20) Major (316) Moderate (11)

Major

Aripiprazole Injection Abametapir Increased exposure of CYP3A4 substrate Details Aripiprazole Injection Abiraterone Acetate Abirtega Increased CYP2D6 substrate exposure and an increased risk of CYP2D6 substrate-related adverse effects Details Aripiprazole Injection Abiraterone Acetate, Micronized Abirtega Increased CYP2D6 substrate exposure and an increased risk of CYP2D6 substrate-related adverse effects Details Aripiprazole Injection Adagrasib Krazati Increased ARIPiprazole exposure and an increased risk of QT interval prolongation Details Aripiprazole Injection Alfentanil Increased risk of respiratory or CNS depression and hypotension Details Aripiprazole Injection Alfuzosin UroXatral An increased risk of QT interval prolongation Details Aripiprazole Injection Alprazolam Xanax Increased risk of CNS depression Details Aripiprazole Injection Amiodarone Nexterone An increased risk of QT interval prolongation and torsade de pointes Details Aripiprazole Injection Amisulpride Barhemsys Increased risk of serious ventricular arrhythmias such as torsades de pointes Details Aripiprazole Injection Amitriptyline Elavil An increased risk of QT interval prolongation Details Aripiprazole Injection Anagrelide Agrylin An increased risk of QT interval prolongation Details Aripiprazole Injection Apalutamide Erleada Reduced ARIPiprazole exposure Details Aripiprazole Injection Apomorphine Apokyn An increased risk of QT interval prolongation Details Aripiprazole Injection Arsenic Trioxide Trisenox An increased risk of QT interval prolongation Details Aripiprazole Injection Artemether An increased risk of QT interval prolongation, reduced CYP3A4 substrates exposure and reduced efficacy of CYP3A4 substrates Details Aripiprazole Injection Asenapine Saphris An increased risk of QT interval prolongation Details Aripiprazole Injection Astemizole An increased risk of QT interval prolongation Details Aripiprazole Injection Atazanavir Reyataz An increased risk of QT interval prolongation Details Aripiprazole Injection Avacopan Tavneos Increased CYP3A4 substrate exposure Details Aripiprazole Injection Azithromycin AzaSite An increased risk of QT interval prolongation Details Aripiprazole Injection Bedaquiline Sirturo An increased risk of QT interval prolongation Details Aripiprazole Injection Bentazepam An increased risk of sedation and orthostatic hypotension Details Aripiprazole Injection Benzhydrocodone Increased risk of respiratory and CNS depression Details Aripiprazole Injection Boceprevir Increased ARIPiprazole exposure Details Aripiprazole Injection Bromazepam Increased risk of respiratory or cardiovascular depression Details Aripiprazole Injection Buprenorphine Belbuca An increased risk of QT interval prolongation and an increased risk of CNS and respiratory depression Details Aripiprazole Injection Bupropion Aplenzin Increased ARIPiprazole exposure Details Aripiprazole Injection Butalbital An increased risk of CNS depression Details Aripiprazole Injection Butorphanol Butorphic Increased risk of respiratory and CNS depression Details Aripiprazole Injection Cabergoline Dostinex® Reduced efficacy of cabergoline and reduced efficacy of dopamine-2 receptors Details Aripiprazole Injection Calcium Oxybate Xywav An increased risk of CNS depression and clinically significant respiratory depression, obtundation, hypotension, profound sedation... Details Aripiprazole Injection Cannabidiol Epidiolex Increased risk of CNS depression and an increased risk of sedation and somnolence Details Aripiprazole Injection Cannabis An increased risk of CNS depression Details Aripiprazole Injection Carbamazepine Carbatrol Reduced ARIPiprazole exposure and an increased risk of respiratory depression, profound sedation, hypotension and syncope Details Aripiprazole Injection Carbidopa Lodosyn An increased risk of CNS depression Details Aripiprazole Injection Carbinoxamine Carbzah An increased risk of CNS depression Details Aripiprazole Injection Celecoxib Celebrex Increased CYP2D6 substrate exposure and an increased risk of CYP2D6 substrate-related adverse effects Details Aripiprazole Injection Ceritinib Zykadia Increased ARIPiprazole exposure and an increased risk of QT interval prolongation Details Aripiprazole Injection Cetirizine Aller-Tec Increased risk of CNS depression Details Aripiprazole Injection Chlordiazepoxide An increased risk of sedation and orthostatic hypotension Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.