Aripiprazole Injection

347 interactions 801 cited references

Also sold as: Abilify Abilify Maintena® Abilify® Aristad Initio® Aristada® Opipza

About Aripiprazole Injection

Aripiprazole extended-release injection (Abilify Maintena, Aristada, Aristada Initio) is used alone or in combination with other aripiprazole preparations to treat schizophrenia (a mental illness that causes disturbed or unusual thinking, loss of interest in life, and strong or inappropriate emotions). Aripiprazole ext… Read the full Aripiprazole Injection drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 12, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Mavorixafor Mesoridazine Metoclopramide Pimozide Piperaquine Posaconazole

20 Contraindicated 316 Major 11 Moderate

All (347) Contraindicated (20) Major (316) Moderate (11)

Major

Aripiprazole Injection Daridorexant An increased risk CNS depression Details Aripiprazole Injection Darunavir Increased ARIPiprazole exposure and an increased risk of ARIPiprazole-related adverse effects Details Aripiprazole Injection Dasatinib Phyrago An increased risk of QT interval prolongation Details Aripiprazole Injection Degarelix Firmagon Increased risk of QT interval prolongation Details Aripiprazole Injection Delamanid An increased risk of QT interval prolongation Details Aripiprazole Injection Delorazepam An increased risk of sedation and orthostatic hypotension Details Aripiprazole Injection Desflurane Suprane An increased risk of QT interval prolongation Details Aripiprazole Injection Desipramine Norpramin An increased risk of QT interval prolongation Details Aripiprazole Injection Desvenlafaxine Pristiq Increased CYP2D6 substrate exposure and an increased risk of CYP2D6 substrate-related adverse events Details Aripiprazole Injection Deutetrabenazine Austedo An increased risk of QT interval prolongation Details Aripiprazole Injection Dexmedetomidine Dexased Increased risk of cardiac arrhythmias and increased risk of CNS depression Details Aripiprazole Injection Diazepam Diastat Increased risk of CNS depression and orthostatic hypotension Details Aripiprazole Injection Dihydrocodeine Increased risk of respiratory and CNS depression Details Aripiprazole Injection Disopyramide Norpace An increased risk of QT interval prolongation Details Aripiprazole Injection Dofetilide Tikosyn An increased risk of QT interval prolongation Details Aripiprazole Injection Dolasetron Anzemet An increased risk of QT interval prolongation Details Aripiprazole Injection Domperidone An increased risk of QT interval prolongation Details Aripiprazole Injection Donepezil Adlarity Increased risk of QT-interval prolongation and torsade de pointes Details Aripiprazole Injection Dordaviprone An increased risk of QT interval prolongation Details Aripiprazole Injection Doxepin Prudoxin An increased risk of CNS depression and an increased risk of QT interval prolongation Details Aripiprazole Injection Doxylamine Aldex AN Increased risk of CNS depression Details Aripiprazole Injection Droperidol An increased risk of QT interval prolongation and an increased risk of CNS depression Details Aripiprazole Injection Duloxetine Increased CYP2D6 substrate exposure Details Aripiprazole Injection Ebastine An increased risk of QT interval prolongation Details Aripiprazole Injection Efavirenz An increased risk of QT interval prolongation Details Aripiprazole Injection Encorafenib Braftovi Reduced ARIPiprazole or ARIPiprazole lauroxil (prodrug of ARIPiprazole) exposure and an increased risk of QT interval prolongation Details Aripiprazole Injection Entrectinib Rozlytrek An increased risk of QT interval prolongation Details Aripiprazole Injection Enzalutamide Xtandi Reduced ARIPiprazole exposure Details Aripiprazole Injection Eribulin Halaven An increased risk of QT interval prolongation Details Aripiprazole Injection Erythromycin Erythrocin Stearate An increased risk of QT interval prolongation, an increased ARIPiprazole or ARIPiprazole lauroxil exposure and an increased risk o... Details Aripiprazole Injection Escitalopram Lexapro An increased risk of QT interval prolongation and increased CYP2D6 substrate exposure Details Aripiprazole Injection Esketamine Spravato Increased risk of sedation Details Aripiprazole Injection Estazolam An increased risk of sedation and orthostatic hypotension Details Aripiprazole Injection Etrasimod Velsipity Increased risk of transient reduction in heart rate, AV conduction, QT interval prolongation and an increased risk of torsade de p... Details Aripiprazole Injection Famotidine Calmicid An increased risk of QT interval prolongation Details Aripiprazole Injection Fedratinib Inrebic Increased CYP3A4/CYP2D6 substrate exposure Details Aripiprazole Injection Felbamate Felbatol An increased risk of QT interval prolongation Details Aripiprazole Injection Fentanyl Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Aripiprazole Injection Fexinidazole Increased exposure of CYP3A4 substrate; increased risk of QT interval prolongation and arrhythmias Details Aripiprazole Injection Fingolimod Gilenya An increased risk of QT interval prolongation Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.