Aripiprazole Injection

347 interactions 801 cited references

Also sold as: Abilify Abilify Maintena® Abilify® Aristad Initio® Aristada® Opipza

About Aripiprazole Injection

Aripiprazole extended-release injection (Abilify Maintena, Aristada, Aristada Initio) is used alone or in combination with other aripiprazole preparations to treat schizophrenia (a mental illness that causes disturbed or unusual thinking, loss of interest in life, and strong or inappropriate emotions). Aripiprazole ext… Read the full Aripiprazole Injection drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 12, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Mavorixafor Mesoridazine Metoclopramide Pimozide Piperaquine Posaconazole

20 Contraindicated 316 Major 11 Moderate

All (347) Contraindicated (20) Major (316) Moderate (11)

Major

Aripiprazole Injection Doxylamine Aldex AN Increased risk of CNS depression Details Aripiprazole Injection Droperidol An increased risk of QT interval prolongation and an increased risk of CNS depression Details Aripiprazole Injection Duloxetine Increased CYP2D6 substrate exposure Details Aripiprazole Injection Ebastine An increased risk of QT interval prolongation Details Aripiprazole Injection Efavirenz An increased risk of QT interval prolongation Details Aripiprazole Injection Encorafenib Braftovi Reduced ARIPiprazole or ARIPiprazole lauroxil (prodrug of ARIPiprazole) exposure and an increased risk of QT interval prolongation Details Aripiprazole Injection Entrectinib Rozlytrek An increased risk of QT interval prolongation Details Aripiprazole Injection Enzalutamide Xtandi Reduced ARIPiprazole exposure Details Aripiprazole Injection Eribulin Halaven An increased risk of QT interval prolongation Details Aripiprazole Injection Erythromycin Erythrocin Stearate An increased risk of QT interval prolongation, an increased ARIPiprazole or ARIPiprazole lauroxil exposure and an increased risk o... Details Aripiprazole Injection Escitalopram Lexapro An increased risk of QT interval prolongation and increased CYP2D6 substrate exposure Details Aripiprazole Injection Esketamine Spravato Increased risk of sedation Details Aripiprazole Injection Estazolam An increased risk of sedation and orthostatic hypotension Details Aripiprazole Injection Etrasimod Velsipity Increased risk of transient reduction in heart rate, AV conduction, QT interval prolongation and an increased risk of torsade de p... Details Aripiprazole Injection Famotidine Calmicid An increased risk of QT interval prolongation Details Aripiprazole Injection Fedratinib Inrebic Increased CYP3A4/CYP2D6 substrate exposure Details Aripiprazole Injection Felbamate Felbatol An increased risk of QT interval prolongation Details Aripiprazole Injection Fentanyl Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Aripiprazole Injection Fexinidazole Increased exposure of CYP3A4 substrate; increased risk of QT interval prolongation and arrhythmias Details Aripiprazole Injection Fingolimod Gilenya An increased risk of QT interval prolongation Details Aripiprazole Injection Flecainide Tambocor® An increased risk of QT interval prolongation Details Aripiprazole Injection Flibanserin Addyi Increased risk of CNS depression Details Aripiprazole Injection Flunitrazepam An increased risk of sedation and orthostatic hypotension Details Aripiprazole Injection Fluoxetine RECONCILE Increased ARIPiprazole exposure and an increased risk of QT interval prolongation Details Aripiprazole Injection Flurazepam An increased risk of sedation and orthostatic hypotension Details Aripiprazole Injection Formoterol Perforomist An increased risk of QT interval prolongation Details Aripiprazole Injection Foscarbidopa An increased risk of CNS depression Details Aripiprazole Injection Foscarnet Foscavir An increased risk of QT interval prolongation Details Aripiprazole Injection Fosfomycin Contepo An increased risk of QT interval prolongation Details Aripiprazole Injection Foslevodopa An increased risk of CNS depression Details Aripiprazole Injection Fosnetupitant Increased exposure of CYP3A4 substrate Details Aripiprazole Injection Fosphenytoin Cerebyx Reduced ARIPiprazole or ARIPiprazole lauroxil (prodrug of ARIPiprazole) exposure and an increased risk of QT interval prolongation Details Aripiprazole Injection Fostemsavir Rukobia Increased risk of torsade de pointes Details Aripiprazole Injection Gabapentin Gabarone An increased risk of respiratory depression and sedation Details Aripiprazole Injection Gabapentin Enacarbil Horizant An increased risk of respiratory depression Details Aripiprazole Injection Galantamine Razadyne An increased risk of QT interval prolongation Details Aripiprazole Injection Gatifloxacin Zymaxid An increased risk of QT interval prolongation Details Aripiprazole Injection Gemifloxacin Factive An increased risk of QT interval prolongation Details Aripiprazole Injection Gepirone Exxua An increased risk of QT interval prolongation and cardiac arrhythmias Details Aripiprazole Injection Gepotidacin Blujepa An increased risk of QT interval prolongation Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.