Aripiprazole Injection

347 interactions 801 cited references

Also sold as: Abilify Abilify Maintena® Abilify® Aristad Initio® Aristada® Opipza

About Aripiprazole Injection

Aripiprazole extended-release injection (Abilify Maintena, Aristada, Aristada Initio) is used alone or in combination with other aripiprazole preparations to treat schizophrenia (a mental illness that causes disturbed or unusual thinking, loss of interest in life, and strong or inappropriate emotions). Aripiprazole ext… Read the full Aripiprazole Injection drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 12, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Mavorixafor Mesoridazine Metoclopramide Pimozide Piperaquine Posaconazole

20 Contraindicated 316 Major 11 Moderate

All (347) Contraindicated (20) Major (316) Moderate (11)

Major

Aripiprazole Injection Insulin Glargine, Recombinant Basaglar An increased risk of hypoglycemia Details Aripiprazole Injection Insulin Icodec-Abae Awiqli Reduced efficacy of insulin icodec-abae Details Aripiprazole Injection Isoflurane Fluriso An increased risk of QT interval prolongation and torsade de pointes Details Aripiprazole Injection Itraconazole Sporanox Increased ARIPiprazole exposure and an increased risk of QT interval prolongation Details Aripiprazole Injection Ivabradine Corlanor An increased risk of QT interval prolongation Details Aripiprazole Injection Ivosidenib Tibsovo Reduced ARIPiprazole or ARIPiprazole lauroxil (prodrug of ARIPiprazole) exposure and an increased risk of QT interval prolongation Details Aripiprazole Injection Ketamine Increased risk of respiratory and CNS depression Details Aripiprazole Injection Ketazolam An increased risk of sedation and orthostatic hypotension Details Aripiprazole Injection Kratom Increased CYP3A substrate exposure and an increased risk of CNS depression Details Aripiprazole Injection Lacosamide Motpoly An increased risk of CNS depression Details Aripiprazole Injection Lapatinib Tykerb An increased risk of QT interval prolongation Details Aripiprazole Injection Lefamulin Xenleta Increased risk of QT interval prolongation Details Aripiprazole Injection Lemborexant Dayvigo An increased risk of CNS depression and potential next-day somnolence Details Aripiprazole Injection Lenvatinib Lenvima Increased risk of QT-interval prolongation Details Aripiprazole Injection Letermovir Prevymis Increased CYP3A substrate exposure Details Aripiprazole Injection Leuprolide Eligard Increased risk of QT interval prolongation Details Aripiprazole Injection Levocetirizine Xyzal Increased risk of CNS depression Details Aripiprazole Injection Levodopa Inbrija An increased risk of CNS depression Details Aripiprazole Injection Levofloxacin Levaquin An increased risk of QT interval prolongation Details Aripiprazole Injection Levorphanol Xyvona An increased risk of respiratory and CNS depression Details Aripiprazole Injection Lofexidine Increased risk of CNS depressant effects and increased risk of QT interval prolongation Details Aripiprazole Injection Lonafarnib Zokinvy Increased ARIPiprazole exposure and an increased risk of QT interval prolongation and torsade de pointes Details Aripiprazole Injection Loperamide Diamode An increased risk of QT interval prolongation, which may increase risk of cardiotoxicity (torsade de pointes, cardiac arrest) Details Aripiprazole Injection Loprazolam An increased risk of sedation and orthostatic hypotension Details Aripiprazole Injection Lorazepam Ativan An increased risk of sedation and orthostatic hypotension Details Aripiprazole Injection Lormetazepam An increased risk of sedation and orthostatic hypotension Details Aripiprazole Injection Loxapine Adasuve Potentiation of impaired cognitive function and motor skills and an increased risk of respiratory depression, hypotension, profoun... Details Aripiprazole Injection Lumacaftor Reduced ARIPiprazole exposure Details Aripiprazole Injection Lumefantrine Increased CYP2D6 substrates exposure and an increased risk of QT prolongation Details Aripiprazole Injection Macimorelin Increased risk of QT interval prolongation Details Aripiprazole Injection Magnesium Oxybate Xywav An increased risk of CNS depression and clinically significant respiratory depression, obtundation, hypotension, profound sedation... Details Aripiprazole Injection Medazepam An increased risk of sedation and orthostatic hypotension Details Aripiprazole Injection Mefloquine Lariam® An increased risk of QT interval prolongation Details Aripiprazole Injection Meperidine Demerol Increased risk of respiratory depression, profound sedation, hypotension, coma and death Details Aripiprazole Injection Metaclazepam An increased risk of sedation and orthostatic hypotension Details Aripiprazole Injection Methadone Diskets Increased risk of respiratory and CNS depression and an increased risk of QT prolongation Details Aripiprazole Injection Methocarbamol Atmeksi An increased risk of CNS depression Details Aripiprazole Injection Methotrimeprazine An increased risk of QT interval prolongation Details Aripiprazole Injection Metronidazole Flagyl An increased risk of QT interval prolongation Details Aripiprazole Injection Midazolam An increased risk of sedation and orthostatic hypotension Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.