Becaplermin Topical and Cat's Claw: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Becaplermin Topical
Cat's Claw
No brand names on record
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Increased risk of bleeding
Interaction Deep Dive
Theoretically, the antiplatelet effect of cat's claw may increase the risk of bleeding when used with antiplatelet agents1. Cat's claw contains rhynochophylline, which may inhibit platelet aggregation.
Why it happens (mechanism)
Inhibition of platelet aggregation by cat's claw
Common questions
Can I take Becaplermin Topical and Cat's Claw together?
Increased risk of bleeding Always confirm with your pharmacist or prescriber before making any change.
How serious is the Becaplermin Topical and Cat's Claw interaction?
It is rated moderate. Can be significant — usually manageable with monitoring.
How quickly could this interaction happen?
The documented onset is "delayed". Effects tend to build up gradually over days to weeks.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
From our Q&A
Real reader questions about these medications, each personally answered by our pharmacist:
Questions for your pharmacist
- Does my dose of Becaplermin Topical or Cat's Claw need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there anything you'd monitor while I'm on both?
References (1)
- Kowalak JF & Mills EJKowalak JF & Mills EJ (Eds): Professional Guide to Complementary & Alternative Therapies, Springhouse Corp. Bethlehem Pike, PA, 2001.
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