Belatacept Injection and Antithymocyte Globulin Equine: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Belatacept Injection
Antithymocyte Globulin Equine
No brand names on record
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Increased risk of venous thrombosis of the renal allograft
Interaction Deep Dive
Coadministration of the first belatacept dose with an antithymocyte globulin, at the same or nearly the same time, in de novo kidney transplant recipients may increase risk for venous thrombosis of the renal allograft. Postmarketing experience has recorded allograft thrombosis with coadministration of first doses of both belatacept and antithymocyte globulin in some patients with additional risk factors for thrombosis. If concomitant use of antithymocyte globulin, or any other cell-depleting induction treatment, is required, separate agents by 12 hours1.
Why it happens (mechanism)
Unknown
Common questions
Can I take Belatacept Injection and Antithymocyte Globulin Equine together?
Increased risk of venous thrombosis of the renal allograft Always confirm with your pharmacist or prescriber before making any change.
How serious is the Belatacept Injection and Antithymocyte Globulin Equine interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
Questions for your pharmacist
- Does my dose of Belatacept Injection or Antithymocyte Globulin Equine need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (1)
- Product Information: NULOJIX intravenous injection, belatacept intravenous injection. Bristol-Myers Squibb Company (per FDA), Princeton, NJ, 2017. DailyMed
Keep reading about Belatacept Injection
Keep reading about Antithymocyte Globulin Equine
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