Belzutifan

Name: Belzutifan Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

49 interactions 7 explained in plain English

Also sold as: Welireg

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Acetaminophen And Codeine Dasatinib Obeticholic Acid Levonorgestrel Intrauterine System Esomeprazole Olaparib

47 Major 2 Moderate

All (49) Major (47) Moderate (2)

Major

Belzutifan Medroxyprogesterone Amen® An increased belzutifan exposure, an increased risk of belzutifan-related adverse effects, reduced hormonal contraceptives exposur... Details Belzutifan Medroxyprogesterone Injection Depo-Provera An increased belzutifan exposure, an increased risk of belzutifan-related adverse effects, reduced hormonal contraceptives exposur... Details Belzutifan Midostaurin Rydapt Reduced CYP3A4 substrates with NTI exposure and reduced efficacy of CYP3A4 substrates with NTI Details Belzutifan Neratinib Nerlynx Reduced CYP3A4 substrates with NTI exposure and reduced efficacy of CYP3A4 substrates with NTI Details Belzutifan Nifedipine Adalat® Reduced NIFEdipine exposure Details Belzutifan Obeticholic Acid Ocaliva Increased belzutifan exposure and an increased risk of belzutifan-related adverse reactions Details Belzutifan Olaparib Lynparza Reduced CYP3A4 substrates with NTI exposure and reduced efficacy of CYP3A4 substrates with NTI Details

Moderate

Belzutifan Hydrocortisone Ala-Cort Reduced hydrocortisone exposure Details Belzutifan Hydrocortisone Injection A-Hydrocort® Reduced hydrocortisone exposure Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.