Cholecalciferol and Mineral Oil: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Cholecalciferol
No brand names on recordMineral Oil
No brand names on record
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Decreased systemic cholecalciferol (vitamin D) concentrations
Interaction Deep Dive
Co-administration of cholecalciferol and mineral oil may reduce exposure to vitamin D and may result in adverse events related to vitamin D deficiency, including hypocalcemia and secondary hyperparathyroidism1.
Why it happens (mechanism)
Reduced vitamin D absorption
Common questions
Can I take Cholecalciferol and Mineral Oil together?
Decreased systemic cholecalciferol (vitamin D) concentrations Always confirm with your pharmacist or prescriber before making any change.
How serious is the Cholecalciferol and Mineral Oil interaction?
It is rated minor. Usually limited clinical impact.
How quickly could this interaction happen?
The documented onset is "delayed". Effects tend to build up gradually over days to weeks.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
Questions for your pharmacist
- Does my dose of Cholecalciferol or Mineral Oil need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there anything you'd monitor while I'm on both?
References (1)
- Product Information: FOSAMAX PLUS D(TM) Tablet, alendronate sodium/ cholecalciferol tablets. Merck & Co. Inc. Whitehouse Station, NJ, USA, 2005. DailyMed
Keep reading about Mineral Oil
These medications also interact with supplements
Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
major · moderate · minor — check everything you take with our drug–supplement interaction checker.
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