Clindamycin Vaginal and Mitotane: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Mitotane
Clindamycin Vaginal
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Reduced CYP3A substrate with NTI exposure and reduced efficacy of CYP3A substrate with NTI exposure
Interaction Deep Dive
Concomitant use of mitotane (strong CYP3A inducer) may decrease the concentration of CYP3A substrates, which may reduce the efficacy of these substrates. Avoid the concomitant use of mitotane with certain CYP3A substrates where minimal concentration changes may lead to therapeutic failure. If concomitant use cannot be avoided, increase the CYP3A substrate dosage as appropriate1.
Why it happens (mechanism)
Induction of CYP3A4-substrate metabolism by mitotane
Common questions
Can I take Clindamycin Vaginal and Mitotane together?
Reduced CYP3A substrate with NTI exposure and reduced efficacy of CYP3A substrate with NTI exposure Always confirm with your pharmacist or prescriber before making any change.
How serious is the Clindamycin Vaginal and Mitotane interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
Questions for your pharmacist
- Does my dose of Clindamycin Vaginal or Mitotane need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (1)
- Product Information: LYSODREN(R) oral tablets, mitotane oral tablets. HRA Pharma Rare Diseases (per FDA), New York, NY, 2024. DailyMed
Keep reading about Mitotane
Keep reading about Clindamycin Vaginal
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Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
major · moderate · minor — check everything you take with our drug–supplement interaction checker.
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