Drug Interaction Report

Clindamycin Vaginal and Taurursodiol: Interaction Details

Name: Clindamycin Vaginal and Taurursodiol Interaction
Creator: Dr. Brian Staiger, PharmD, BCPS

A pharmacist-reviewed analysis of the Clindamycin Vaginal and Taurursodiol interaction: the documented clinical effects, severity rating, onset, mechanism, and management considerations, with cited references throughout.

AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature

Clindamycin Vaginal

Cleocin Cleocin® Vaginal Suppository Clindesse Clindesse® Vaginal Cream

Taurursodiol

No brand names on record

Medically reviewed by

Dr. Brian Staiger, PharmD, BCPS

Updated Aug 8, 2026

Editorial policy · Data sources

Interaction severity

Major

Potentially serious — often needs a change or close monitoring.

Minor

Moderate

Major

Contraindicated

How we grade severity & evidence

Severity levels

Contraindicated: These should generally not be used together.
Major: Potentially serious — often needs a change or close monitoring.
Moderate: Can be significant — usually manageable with monitoring.
Minor: Usually limited clinical impact.

Evidence grades

Established: Well documented — supported by controlled studies or strong clinical data.
Probable: Good supporting evidence, though not definitively proven.
Suspected: Some evidence suggests this interaction, but it is not well established.
Possible: Limited or conflicting evidence; the interaction may occur.
Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.

Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.

Of 78 documented Clindamycin Vaginal interactions, 57 are rated major — including this one.

Worried about symptoms right now? Contact your pharmacist or prescriber, or call Poison Control at 1-800-222-1222 (US). Call 911 for an emergency.

Onset

unspecified

Evidence

theoretical

Severity

Major

What happens

Decreased exposure of the CYP3A4 substrate

Interaction Deep Dive

Concomitant use of sodium phenylbutyrate/taurursodiol (a CYP3A4 inducer) with a CYP3A4 substrate may result in decreased substrate exposure. Avoid use with CYP3A4 substrates where a small change in substrate plasma concentration may lead to serious toxicities or loss of efficacy¹.

Why it happens (mechanism)

Induction of CYP3A4 substrate metabolism by sodium phenylbutyrate/taurursodiol

Common questions

Can I take Clindamycin Vaginal and Taurursodiol together?

Decreased exposure of the CYP3A4 substrate Always confirm with your pharmacist or prescriber before making any change.

How serious is the Clindamycin Vaginal and Taurursodiol interaction?

It is rated major. Potentially serious — often needs a change or close monitoring.

How quickly could this interaction happen?

The documented onset is "unspecified". The timing of this interaction is not well characterized.

How strong is the evidence for this interaction?

The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.

Questions for your pharmacist

Does my dose of Clindamycin Vaginal or Taurursodiol need adjusting while I take them together?
What symptoms should prompt me to call you or my prescriber right away?
Does the timing of my doses matter for this combination?
Is there a safer alternative to one of these medications for me?

References (1)

Product Information: RELYVRIO(TM) oral powder for suspension, sodium phenylbutyrate taurursodiol oral powder for suspension. Amylyx Pharmaceuticals Inc (per FDA), Cambridge, MA, 2022.

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Clindamycin Vaginal

Keep reading about Clindamycin Vaginal

All Clindamycin Vaginal interactions (78) Clindamycin Vaginal drug information

Also serious with: Mifepristone Levoketoconazole Ensitrelvir Apalutamide

Taurursodiol

Keep reading about Taurursodiol

All Taurursodiol interactions (31)

Also serious with: Dasatinib Clindamycin Topical Abemaciclib Olaparib

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HelloPharmacist doesn't license one of the big commercial interaction databases, so what you'll find here is not a complete list of every known drug interaction. Instead, each entry is researched, analyzed, and written up individually — documented from the published literature, reviewed by a pharmacist, and cited so you can check every source yourself.

If a combination isn't listed here, it means we haven't documented it yet — never that it's safe. For screening a full medication list, we recommend pairing this site with a comprehensive tool like the Drugs.com Interaction Checker and, most importantly, a review by your own pharmacist. For a deep, plain-English, fully sourced explanation of a specific documented interaction — that's exactly what we built this for.

This information is for education, not a substitute for professional medical advice. Do not start, stop, or change any medication without talking to your pharmacist or prescriber.