Drug Interaction Report

Clorgyline and Levodopa Oral Inhalation: Interaction Details

A pharmacist-reviewed analysis of the Clorgyline and Levodopa Oral Inhalation interaction: the documented clinical effects, severity rating, onset, mechanism, and management considerations, with cited references throughout.

AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature

Levodopa Oral Inhalation

Inbrija Inbrija®
+

Clorgyline

No brand names on record
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
Updated Aug 8, 2026
Editorial policy · Data sources
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Interaction severity
Contraindicated
These should generally not be used together.
How we grade severity & evidence

Severity levels

  • Contraindicated: These should generally not be used together.
  • Major: Potentially serious — often needs a change or close monitoring.
  • Moderate: Can be significant — usually manageable with monitoring.
  • Minor: Usually limited clinical impact.

Evidence grades

  • Established: Well documented — supported by controlled studies or strong clinical data.
  • Probable: Good supporting evidence, though not definitively proven.
  • Suspected: Some evidence suggests this interaction, but it is not well established.
  • Possible: Limited or conflicting evidence; the interaction may occur.
  • Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.

Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.

Worried about symptoms right now? Contact your pharmacist or prescriber, or call Poison Control at 1-800-222-1222 (US). Call 911 for an emergency.
Onset
rapid
Evidence
theoretical
Severity
Contraindicated

What happens

Hypertension

Interaction Deep Dive

Concurrent administration of levodopa with monoamine oxidase inhibitors (MAOIs) has resulted in hypertensive reactions21, and therefore is contraindicated 3.

Why it happens (mechanism)

Increased dopamine and/or norepinephrine availability

Common questions

Can I take Clorgyline and Levodopa Oral Inhalation together?

Hypertension Always confirm with your pharmacist or prescriber before making any change.

How serious is the Clorgyline and Levodopa Oral Inhalation interaction?

It is rated contraindicated. These should generally not be used together.

How quickly could this interaction happen?

The documented onset is "rapid". Effects can appear quickly, often within about 24 hours of combining the drugs.

How strong is the evidence for this interaction?

The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.

Questions for your pharmacist

  • Does my dose of Clorgyline or Levodopa Oral Inhalation need adjusting while I take them together?
  • What symptoms should prompt me to call you or my prescriber right away?
  • Does the timing of my doses matter for this combination?
  • Is there a safer alternative to one of these medications for me?

References (3)

  1. Hodge JV: Use of monoamine-oxidase inhibitors. Lancet 1965; 1:764. DOI
  2. Hunter KR, Boakes AJ, Laurence DR, et al: Monoamine oxidase inhibitors and L-dopa. Br Med J 1970; 3:388. PubMed
  3. Product Information: Larodopa(R), levodopa. Roche Laboratories Inc. Nutley, NJ, 1997. DailyMed
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Levodopa Oral Inhalation

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