Colchicine

223 interactions 184 explained in plain English 621 cited references

Also sold as: Colcrys Colcrys® Gloperba Gloperba® Lodoco Mitigare

About Colchicine

Colchicine is used to prevent gout attacks (sudden, severe pain in one or more joints caused by abnormally high levels of a substance called uric acid in the blood) in adults. Colchicine (Colcrys) is also used to relieve the pain of gout attacks when they occur. Colchicine (Colcrys) is also used to treat familial Medit… Read the full Colchicine drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 2, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Zanubrutinib Ketoconazole Topical Alogliptin Amiodarone Atazanavir Asunaprevir

103 Contraindicated 107 Major 9 Moderate 4 Minor

All (223) Contraindicated (103) Major (107) Moderate (9) Minor (4)

Contraindicated

Colchicine Alogliptin Nesina Increased colchicine exposure and an increased risk of colchicine toxicity Details Colchicine Amiodarone Nexterone Explained Increased colchicine exposure and an increased risk of fatal toxicity Details Colchicine Asunaprevir Explained Increased colchicine exposure and an increased risk of colchicine toxicity Details Colchicine Atazanavir Reyataz Explained Increased colchicine exposure and an increased risk of colchicine toxicity Details Colchicine Atorvastatin Atorvaliq Increased colchicine exposure, an increased risk of colchicine toxicity and an increased risk of myopathy and rhabdomyolysis Details Colchicine Azithromycin AzaSite Explained Increased colchicine exposure and an increased risk of colchicine toxicity Details Colchicine Berotralstat Orladeyo Explained Increased colchicine exposure and an increased risk of fatal toxicity Details Colchicine Boceprevir Explained Increased colchicine exposure and an increased risk of fatal toxicity Details Colchicine Canagliflozin Invokana Increased colchicine exposure and an increased risk of colchicine toxicity Details Colchicine Captopril Capoten® Increased colchicine exposure and an increased risk of colchicine toxicity Details Colchicine Carvedilol Coreg Explained Increased colchicine exposure and an increased risk of colchicine toxicity Details Colchicine Ceritinib Zykadia Explained Increased colchicine exposure and an increased risk of fatal toxicity Details Colchicine Cimetidine Tagamet Explained Increased colchicine exposure and an increased risk of fatal toxicity Details Colchicine Clarithromycin Biaxin Explained Increased colchicine exposure and an increased risk of colchicine toxicity Details Colchicine Cobicistat Tybost Explained Increased colchicine exposure and an increased risk of colchicine toxicity Details Colchicine Conivaptan Vaprisol Explained Increased colchicine exposure and an increased risk of colchicine toxicity Details Colchicine Cyclosporine Atopica Explained Increased colchicine and cycloSPORINE exposure Details Colchicine Daclatasvir Daklinza® Explained Increased colchicine exposure and an increased risk of colchicine toxicity Details Colchicine Darunavir Explained Increased colchicine exposure and an increased risk of colchicine toxicity Details Colchicine Diltiazem Cardizem Explained Increased colchicine exposure and an increased risk of fatal toxicity Details Colchicine Diosmin Explained Increased colchicine exposure and an increased risk of fatal toxicity Details Colchicine Dronedarone Multaq Explained Increased colchicine exposure and an increased risk of colchicine toxicity Details Colchicine Elagolix Orilissa Explained Increased colchicine exposure and an increased risk of colchicine toxicity Details Colchicine Eliglustat Cerdelga Explained Increased colchicine exposure and an increased risk of colchicine toxicity Details Colchicine Enasidenib Idhifa Increased colchicine exposure, an increased risk of colchicine toxicity, reduced colchicine and reduced efficacy of colchicine Details Colchicine Ensitrelvir Explained Increased colchicine exposure and an increased risk of renal and/or hepatic impairment Details Colchicine Entrectinib Rozlytrek Increased colchicine exposure and an increased risk of colchicine toxicity Details Colchicine Enzalutamide Xtandi Explained Altered (increased/reduced) colchicine exposure and an increased risk of colchicine toxicity Details Colchicine Erythromycin Erythrocin Stearate Explained Increased colchicine exposure and an increased risk of colchicine toxicity Details Colchicine Felodipine Plendil® Increased colchicine exposure and an increased risk of colchicine toxicity Details Colchicine Flibanserin Addyi Explained Increased colchicine exposure and an increased risk of colchicine toxicity Details Colchicine Fluvoxamine Explained Increased colchicine exposure and an increased risk of fatal toxicity Details Colchicine Fostamatinib Tavalisse Increased colchicine exposure and an increased risk of colchicine toxicity Details Colchicine Ginkgo Explained Increased colchicine exposure and an increased risk of fatal toxicity Details Colchicine Glecaprevir Explained Increased colchicine exposure and an increased risk of colchicine toxicity Details Colchicine Ibrexafungerp Brexafemme Increased colchicine exposure and an increased risk of colchicine toxicity Details Colchicine Idelalisib Zydelig Explained Increased colchicine exposure and an increased risk of fatal toxicity Details Colchicine Indinavir Explained Increased colchicine exposure and an increased risk of fatal toxicity Details Colchicine Isavuconazole Explained Increased colchicine exposure and an increased risk of fatal toxicity Details Colchicine Isavuconazonium Cresemba Explained Increased colchicine exposure and an increased risk of fatal toxicity Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.