Colchicine

223 interactions 184 explained in plain English 621 cited references

Also sold as: Colcrys Colcrys® Gloperba Gloperba® Lodoco Mitigare

About Colchicine

Colchicine is used to prevent gout attacks (sudden, severe pain in one or more joints caused by abnormally high levels of a substance called uric acid in the blood) in adults. Colchicine (Colcrys) is also used to relieve the pain of gout attacks when they occur. Colchicine (Colcrys) is also used to treat familial Medit… Read the full Colchicine drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 2, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Zanubrutinib Ketoconazole Topical Alogliptin Amiodarone Atazanavir Asunaprevir

103 Contraindicated 107 Major 9 Moderate 4 Minor

All (223) Contraindicated (103) Major (107) Moderate (9) Minor (4)

Contraindicated

Colchicine Istradefylline Nourianz Increased colchicine exposure and an increased risk of fatal toxicity Details Colchicine Itraconazole Sporanox Explained Increased colchicine exposure and an increased risk of colchicine toxicity Details Colchicine Ketoconazole Extina Explained Increased colchicine exposure and an increased risk of colchicine toxicity Details Colchicine Lapatinib Tykerb Explained Increased colchicine exposure and an increased risk of colchicine toxicity Details Colchicine Lasmiditan Reyvow Explained Increased colchicine exposure and an increased risk of colchicine toxicity Details Colchicine Lenacapavir Sunlenca Explained Increased colchicine exposure and an increased risk of colchicine toxicity Details Colchicine Levoketoconazole Recorlev Explained Increased exposure of CYP3A4/P-gp substrate Details Colchicine Lonafarnib Zokinvy Explained Increased colchicine exposure and an increased risk of fatal toxicity Details Colchicine Maribavir Livtencity Explained Increased colchicine exposure and an increased risk of fatal toxicity Details Colchicine Mibefradil Explained Increased colchicine exposure and an increased risk of colchicine toxicity Details Colchicine Mifepristone Korlym Explained Increased colchicine exposure and an increased risk of fatal toxicity Details Colchicine Mirabegron Myrbetriq Explained Increased colchicine exposure and an increased risk of colchicine toxicity Details Colchicine Nefazodone Explained Increased colchicine exposure and an increased risk of fatal toxicity Details Colchicine Nelfinavir Viracept Explained Increased colchicine exposure and an increased risk of fatal toxicity Details Colchicine Nifedipine Adalat® Increased colchicine exposure and an increased risk of colchicine toxicity Details Colchicine Nirmatrelvir Explained Increased colchicine exposure and increased risk of colchicine toxicity Details Colchicine Osimertinib Tagrisso Explained Increased colchicine exposure and an increased risk of colchicine toxicity Details Colchicine Paritaprevir Explained Increased colchicine exposure and an increased risk of fatal toxicity Details Colchicine Paroxetine Paxil Explained Increased colchicine exposure and an increased risk of colchicine toxicity Details Colchicine Pexidartinib Turalio Explained Increased colchicine exposure and an increased risk of colchicine toxicity Details Colchicine Pibrentasvir Explained Increased colchicine exposure and an increased risk of colchicine toxicity Details Colchicine Pirtobrutinib Jaypirca Explained Increased colchicine exposure and an increased risk of colchicine toxicity Details Colchicine Posaconazole Noxafil Explained Increased colchicine exposure and an increased risk of fatal toxicity Details Colchicine Propafenone Rythmol Explained Increased colchicine exposure and an increased risk of colchicine toxicity Details Colchicine Quinidine Cardioquin® Explained Increased colchicine exposure and an increased risk of colchicine toxicity Details Colchicine Quinine Explained Increased colchicine exposure and an increased risk of colchicine toxicity Details Colchicine Ranolazine Aspruzyo Explained Increased colchicine exposure and an increased risk of potential life-threatening toxicity Details Colchicine Ribociclib Kisqali Explained Increased colchicine exposure and an increased risk of fatal toxicity Details Colchicine Rifampin Rifadin Explained Increased colchicine exposure and an increased risk of colchicine toxicity Details Colchicine Ritonavir Norvir Explained Increased colchicine exposure and an increased risk of colchicine toxicity Details Colchicine Rolapitant Varubi Explained Increased colchicine exposure and an increased risk of colchicine toxicity Details Colchicine Rucaparib Rubraca Explained Increased colchicine exposure and an increased risk of colchicine toxicity Details Colchicine Saquinavir Explained Increased colchicine exposure and an increased risk of fatal toxicity Details Colchicine Sarecycline Seysara Explained Increased colchicine exposure and an increased risk of colchicine toxicity Details Colchicine Schizandra Explained Increased colchicine exposure and an increased risk of fatal toxicity Details Colchicine Simeprevir Olysio® Explained Increased colchicine exposure and an increased risk of colchicine toxicity Details Colchicine Sofosbuvir Sovaldi Explained Increased colchicine exposure and an increased risk of colchicine toxicity Details Colchicine Sotagliflozin Inpefa Explained Increased colchicine exposure and an increased risk of colchicine toxicity Details Colchicine Spironolactone Aldactone Explained Increased colchicine exposure and an increased risk of colchicine toxicity Details Colchicine Sunitinib Sutent Explained Increased colchicine plasma concentrations and increased risk of toxicity Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.