Colchicine

223 interactions 184 explained in plain English 621 cited references
Also sold as: Colcrys Colcrys® Gloperba Gloperba® Lodoco Mitigare
About Colchicine

Colchicine is used to prevent gout attacks (sudden, severe pain in one or more joints caused by abnormally high levels of a substance called uric acid in the blood) in adults. Colchicine (Colcrys) is also used to relieve the pain of gout attacks when they occur. Colchicine (Colcrys) is also used to treat familial Medit… Read the full Colchicine drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 2, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Contraindicated

Colchicine Suvorexant Belsomra Explained Increased colchicine exposure and an increased risk of colchicine toxicity Details Colchicine Telaprevir Explained Increased colchicine exposure and an increased risk of colchicine toxicity Details Colchicine Telithromycin Explained Increased colchicine exposure and an increased risk of fatal toxicity Details Colchicine Telmisartan Micardis Explained Increased colchicine exposure and an increased risk of colchicine toxicity Details Colchicine Tepotinib Tepmetko Explained Increased colchicine exposure and an increased risk of colchicine toxicity Details Colchicine Ticagrelor Brilinta Explained Increased colchicine exposure and an increased risk of fatal toxicity Details Colchicine Tipranavir Aptivus Explained Increased colchicine exposure and an increased risk of colchicine toxicity Details Colchicine Tolvaptan Jynarque Explained Increased colchicine exposure and an increased risk of colchicine toxicity Details Colchicine Troleandomycin Explained Increased colchicine exposure and an increased risk of fatal toxicity Details Colchicine Tucatinib Tukysa Explained Increased colchicine exposure and an increased risk of fatal toxicity Details Colchicine Vandetanib Caprelsa Explained Increased colchicine exposure and an increased risk of colchicine toxicity Details Colchicine Velpatasvir Explained Increased colchicine exposure and an increased risk of colchicine toxicity Details Colchicine Vemurafenib Zelboraf Explained Increased colchicine exposure and an increased risk of colchicine toxicity Details Colchicine Verapamil Calan Explained Increased colchicine exposure and an increased risk of colchicine toxicity Details Colchicine Vibegron Gemtesa Explained Increased colchicine exposure and an increased risk of colchicine toxicity Details Colchicine Vorapaxar Zontivity Explained Increased colchicine exposure and an increased risk of colchicine toxicity Details Colchicine Voriconazole Vfend Explained Increased colchicine exposure and an increased risk of fatal toxicity Details Colchicine Zanubrutinib Brukinsa Explained Increased colchicine exposure and an increased risk of colchicine toxicity Details Colchicine Cyclosporine Injection Atopica Increased colchicine and cycloSPORINE exposure Details Colchicine Cyclosporine Ophthalmic Cequa Increased colchicine and cycloSPORINE exposure Details Colchicine Ketoconazole Topical Extina® Foam Increased colchicine exposure and an increased risk of colchicine toxicity Details Colchicine Lenacapavir Injection Sunlenca Increased colchicine exposure and an increased risk of colchicine toxicity Details Colchicine Lenacapavir Oral Sunlenca Increased colchicine exposure and an increased risk of colchicine toxicity Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.