Crizotinib

138 interactions 13 explained in plain English
Also sold as: Xalkori
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ketoconazole Topical Ifosfamide Injection Gatifloxacin Ophthalmic Penbutolol Amitriptyline Brexpiprazole
1 Contraindicated 123 Major 14 Moderate
All (138) Contraindicated (1) Major (123) Moderate (14)

Major

Crizotinib Olaparib Lynparza Increased olaparib exposure Details Crizotinib Olodaterol Oral Inhalation Striverdi An increased risk of QT interval prolongation and an increased risk of ventricular arrhythmias Details Crizotinib Oxaliplatin Injection Eloxatin® Increased risk of QT-interval prolongation Details Crizotinib Penbutolol Levatol® An increased risk of bradycardia Details

Moderate

Crizotinib Simvastatin Flolipid Explained Increased simvastatin exposure Details Crizotinib Abemaciclib Verzenio Explained Increased abemaciclib plasma concentration Details Crizotinib Abiraterone Abirtega Increased crizotinib exposure Details Crizotinib Avanafil Stendra Increased avanafil exposure Details Crizotinib Budesonide Entocort Increased budesonide exposure Details Crizotinib Budesonide Nasal Spray Rhinocort Increased budesonide exposure Details Crizotinib Budesonide Oral Inhalation Pulmicort Increased budesonide exposure Details Crizotinib Felodipine Plendil® Increased felodipine exposure Details Crizotinib Hydrocortisone Ala-Cort Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Crizotinib Hydrocortisone Injection A-Hydrocort® Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Crizotinib Levothyroxine Ermeza Increased risk of hypothyroidism Details Crizotinib Lovastatin Altocor® Increased lovastatin exposure Details Crizotinib Midazolam Nasal Spray Nayzilam Increased midazolam exposure Details Crizotinib Midazolam Injection Nayzilam Increased midazolam exposure Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.