Dalteparin Injection and Collagenase, Clostridium Histolyticum: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Dalteparin Injection
Collagenase, Clostridium Histolyticum
No brand names on record
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Increased risk of bleeding adverse effects
Interaction Deep Dive
Avoid concomitant use of an anticoagulant (except for low-dose aspirin) and collagenase clostridium histolyticum in patients with abnormal coagulation because of increased risk of bleeding events. Interaction studies were not conducted in patients receiving anticoagulant medications within 7 days prior to administration of collagenase clostridium histolyticum1.
Why it happens (mechanism)
Altered coagulation
Common questions
Can I take Dalteparin Injection and Collagenase, Clostridium Histolyticum together?
Increased risk of bleeding adverse effects Always confirm with your pharmacist or prescriber before making any change.
How serious is the Dalteparin Injection and Collagenase, Clostridium Histolyticum interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
Questions for your pharmacist
- Does my dose of Dalteparin Injection or Collagenase, Clostridium Histolyticum need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (1)
- Product Information: XIAFLEX(R) intralesional injection solution, collagenase clostridium histolyticum intralesional injection solution. Auxilium Pharmaceuticals, Inc. (per manufacturer), Chesterbrook, PA, 2013.
Keep reading about Dalteparin Injection
Keep reading about Collagenase, Clostridium Histolyticum
Check another combination
Our instant two-drug interaction checker is almost here.
Still have questions about this combination?
Every question gets a real answer from a licensed pharmacist — free, and usually within a day.
Ask the pharmacist