Drug Interaction Report

Dandelion and Fondaparinux: Interaction Details

A pharmacist-reviewed analysis of the Dandelion and Fondaparinux interaction: the documented clinical effects, severity rating, onset, mechanism, and management considerations, with cited references throughout.

AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature

Fondaparinux

Arixtra
+

Dandelion

No brand names on record
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
Updated Aug 8, 2026
Editorial policy · Data sources
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Interaction severity
Moderate
Can be significant — usually manageable with monitoring.
How we grade severity & evidence

Severity levels

  • Contraindicated: These should generally not be used together.
  • Major: Potentially serious — often needs a change or close monitoring.
  • Moderate: Can be significant — usually manageable with monitoring.
  • Minor: Usually limited clinical impact.

Evidence grades

  • Established: Well documented — supported by controlled studies or strong clinical data.
  • Probable: Good supporting evidence, though not definitively proven.
  • Suspected: Some evidence suggests this interaction, but it is not well established.
  • Possible: Limited or conflicting evidence; the interaction may occur.
  • Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.

Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.

Of 26 documented Dandelion interactions, 26 are rated moderate — including this one.
Onset
delayed
Evidence
theoretical
Severity
Moderate

What happens

Increased risk of bleeding

Interaction Deep Dive

Theoretically, the platelet inhibitory effects and vitamin A content of dandelion may potentiate the effects of anticoagulants213456. Dandelion contains 14,000 international units (IU) of vitamin A per 100 grams of leaf, compared to 11,000 IU vitamin A per 100 grams of carrots 4. Large doses of vitamin A taken concurrently with oral anticoagulants may result in increased anticoagulant effect 5.

Why it happens (mechanism)

Vitamin A content of dandelion may potentiate anticoagulant therapy; inhibition of platelet aggregation by dandelion constituents

Common questions

Can I take Dandelion and Fondaparinux together?

Increased risk of bleeding Always confirm with your pharmacist or prescriber before making any change.

How serious is the Dandelion and Fondaparinux interaction?

It is rated moderate. Can be significant — usually manageable with monitoring.

How quickly could this interaction happen?

The documented onset is "delayed". Effects tend to build up gradually over days to weeks.

How strong is the evidence for this interaction?

The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.

From our Q&A

Real reader questions about these medications, each personally answered by our pharmacist:

Questions for your pharmacist

  • Does my dose of Dandelion or Fondaparinux need adjusting while I take them together?
  • What symptoms should prompt me to call you or my prescriber right away?
  • Does the timing of my doses matter for this combination?
  • Is there anything you'd monitor while I'm on both?

References (6)

  1. Norred CL & Brinker F: Potential coagulation effects of preoperative complementary and alternative medicines. Alt Ther 2001; 7(6):58-67.
  2. Kowalak JF & Mills EJKowalak JF & Mills EJ (Eds): Professional Guide to Complementary & Alternative Therapies, Springhouse Corp. Bethlehem Pike, PA, 2001, pp 175.
  3. Neef H, Cilli F, Declerck PJ, et al: Platelet anti-aggregating activity of Taraxacum officinale Weber. Phytother Res 1996; 10:S138-S140.
  4. Newall CA, Anderson LA, & Phillipson JDNewall CA, Anderson LA, & Phillipson JD: Herbal Medicines: A Guide for Health-Care Professionals, The Pharmaceutical Press, London, England, 1996, pp 96.
  5. Anon: Vitamin supplements. Med Lett Drugs Ther 1985; 27(693):66-68.
  6. Schrogie JJ: Coagulopathy and fat-soluble Vitamins (letter). JAMA 1975; 232:19. DOI
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Fondaparinux

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Dandelion

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Beyond drug–drug

These medications also interact with supplements

Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:

Fondaparinux + Danshen Piracetam Aconite Allspice Aloe Alpha-lipoic Acid Andrographis Arnica + 194 more

major · moderate · minor — check everything you take with our drug–supplement interaction checker.

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This information is for education, not a substitute for professional medical advice. Do not start, stop, or change any medication without talking to your pharmacist or prescriber.