Daridorexant

66 interactions 6 explained in plain English

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Docetaxel Olaparib Buprenorphine Hydromorphone Rectal Dofetilide Fentanyl Transdermal Patch

63 Major 3 Moderate

All (66) Major (63) Moderate (3)

Major

Daridorexant Fentanyl Transdermal Patch Duragesic® Increased CYP3A4 substrate with NTI exposure and an increased risk CNS depression Details Daridorexant Finerenone Kerendia Increased finerenone exposure and an increased risk of finerenone-related adverse effects Details Daridorexant Hydromorphone Injection Dilaudid An increased risk CNS depression Details Daridorexant Hydromorphone Rectal available generically An increased risk CNS depression Details Daridorexant Ketoconazole Topical Extina® Foam Increased daridorexant exposure Details Daridorexant Lacosamide Injection Motpoly An increased risk of CNS depression Details Daridorexant Lefamulin Xenleta Increased lefamulin exposure, an increased risk of lefamulin-related adverse reactions and increased sensitive CYP3A4 substrate ex... Details Daridorexant Lenacapavir Injection Sunlenca Increased sensitive CYP3A substrate exposure and an increased risk of sensitive CYP3A substrate-mediated adverse reactions Details Daridorexant Lenacapavir Oral Sunlenca Increased sensitive CYP3A substrate exposure and an increased risk of sensitive CYP3A substrate-mediated adverse reactions Details Daridorexant Letermovir Injection Prevymis Increased daridorexant exposure Details Daridorexant Levodopa Oral Inhalation Inbrija An increased risk of CNS depression Details Daridorexant Loperamide Diamode An increased loperamide exposure and an increased risk of loperamide-related adverse reactions Details Daridorexant Methylergonovine Methergine Increased methylergonovine exposure Details Daridorexant Midazolam Nasal Spray Nayzilam An increased risk CNS depression Details Daridorexant Midazolam Injection Nayzilam An increased risk CNS depression Details Daridorexant Midostaurin Rydapt Increased CYP3A4 substrate with NTI exposure Details Daridorexant Mitapivat Aqvesme Reduced CYP3A substrate exposure Details Daridorexant Morphine Injection Astramorph® PF An increased risk CNS depression Details Daridorexant Nafcillin Injection Unipen® Injection Reduced daridorexant exposure and reduced efficacy of daridorexant Details Daridorexant Nalbuphine Injection Nubain® An increased risk CNS depression Details Daridorexant Neratinib Nerlynx Increased CYP3A4 substrate with NTI exposure Details Daridorexant Nifedipine Adalat® Increased NIFEdipine exposure Details Daridorexant Olaparib Lynparza Increased CYP3A4 substrate with NTI exposure Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.