Diclofenac Transdermal Patch

268 interactions 703 cited references

Also sold as: Flector Flector® Patch Licart Licart ® Topical System Xiclo

About Diclofenac Transdermal Patch

Transdermal diclofenac is used to treat short-term pain due to minor strains, sprains, and bruises in adults and children 6 years of age and older. Diclofenac is in a class of medications called nonsteroidal anti-inflammatory drugs (NSAIDs). It works by stopping the body's production of a substance that causes pain. Read the full Diclofenac Transdermal Patch drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ketorolac Xipamide Fluorouracil Flufenamic Acid Floctafenine Feverfew

1 Contraindicated 197 Major 70 Moderate

All (268) Contraindicated (1) Major (197) Moderate (70)

Major

Diclofenac Transdermal Patch Abciximab An increased risk of bleeding Details Diclofenac Transdermal Patch Acenocoumarol An increased risk of bleeding Details Diclofenac Transdermal Patch Amiloride Reduced diuretic effectiveness, hyperkalemia, or possible nephrotoxicity Details Diclofenac Transdermal Patch Amineptine An increased risk of bleeding Details Diclofenac Transdermal Patch Amitriptyline Elavil An increased risk of bleeding Details Diclofenac Transdermal Patch Amitriptylinoxide An increased risk of bleeding Details Diclofenac Transdermal Patch Amoxapine An increased risk of bleeding Details Diclofenac Transdermal Patch Anagrelide Agrylin An increased risk of bleeding Details Diclofenac Transdermal Patch Apalutamide Erleada Reduced CYP2C9 substrates exposure Details Diclofenac Transdermal Patch Apixaban Eliquis An increased risk of bleeding Details Diclofenac Transdermal Patch Ardeparin An increased risk of bleeding Details Diclofenac Transdermal Patch Argatroban An increased risk of bleeding Details Diclofenac Transdermal Patch Aspirin Acuprin® An increased risk of bleeding, decreased renal function, and an increased risk of gastrointestinal adverse events Details Diclofenac Transdermal Patch Azathioprine Azasan An increased risk of hepatotoxicity Details Diclofenac Transdermal Patch Bemetizide Reduced diuretic effectiveness and possible nephrotoxicity Details Diclofenac Transdermal Patch Bemiparin An increased risk of bleeding Details Diclofenac Transdermal Patch Bendroflumethiazide Reduced diuretic effectiveness and possible nephrotoxicity Details Diclofenac Transdermal Patch Benzthiazide Reduced diuretic effectiveness and possible nephrotoxicity Details Diclofenac Transdermal Patch Betrixaban Bevyxxa® An increased risk of bleeding Details Diclofenac Transdermal Patch Bivalirudin Angiomax An increased risk of bleeding Details Diclofenac Transdermal Patch Budesonide Entocort Increased risk of gastrointestinal ulcer or bleeding Details Diclofenac Transdermal Patch Bumetanide Bumex Reduced diuretic effectiveness and possible nephrotoxicity Details Diclofenac Transdermal Patch Cangrelor Kengreal An increased risk of bleeding Details Diclofenac Transdermal Patch Capecitabine Xeloda Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Diclofenac Transdermal Patch Ceritinib Zykadia Increased exposure of CYP2C9 substrate Details Diclofenac Transdermal Patch Certoparin An increased risk of bleeding Details Diclofenac Transdermal Patch Chlorothiazide Diuril Reduced diuretic effectiveness and possible nephrotoxicity Details Diclofenac Transdermal Patch Chlorthalidone Hemiclor Reduced diuretic effectiveness and possible nephrotoxicity Details Diclofenac Transdermal Patch Cilostazol Pletal® An increased risk of bleeding Details Diclofenac Transdermal Patch Citalopram Celexa An increased risk of bleeding Details Diclofenac Transdermal Patch Clomipramine Anafranil An increased risk of bleeding Details Diclofenac Transdermal Patch Clopamide Reduced diuretic effectiveness and possible nephrotoxicity Details Diclofenac Transdermal Patch Clopidogrel Plavix An increased risk of bleeding Details Diclofenac Transdermal Patch Cyclopenthiazide Reduced diuretic effectiveness and possible nephrotoxicity Details Diclofenac Transdermal Patch Cyclosporine Atopica An increased risk of cycloSPORINE nephrotoxicity Details Diclofenac Transdermal Patch Cyclothiazide Reduced diuretic effectiveness and possible nephrotoxicity Details Diclofenac Transdermal Patch Dabigatran Etexilate An increased risk of bleeding Details Diclofenac Transdermal Patch Dalteparin Fragmin An increased risk of bleeding Details Diclofenac Transdermal Patch Danaparoid An increased risk of bleeding Details Diclofenac Transdermal Patch Deferiprone Ferriprox Decreased deferiprone clearance and increased deferiprone plasma concentrations Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.