Diclofenac Transdermal Patch

268 interactions 703 cited references

Also sold as: Flector Flector® Patch Licart Licart ® Topical System Xiclo

About Diclofenac Transdermal Patch

Transdermal diclofenac is used to treat short-term pain due to minor strains, sprains, and bruises in adults and children 6 years of age and older. Diclofenac is in a class of medications called nonsteroidal anti-inflammatory drugs (NSAIDs). It works by stopping the body's production of a substance that causes pain. Read the full Diclofenac Transdermal Patch drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ketorolac Xipamide Fluorouracil Flufenamic Acid Floctafenine Feverfew

1 Contraindicated 197 Major 70 Moderate

All (268) Contraindicated (1) Major (197) Moderate (70)

Major

Diclofenac Transdermal Patch Deflazacort Emflaza Increased risk of gastrointestinal ulcer or bleeding Details Diclofenac Transdermal Patch Desipramine Norpramin An increased risk of bleeding Details Diclofenac Transdermal Patch Desirudin Iprivask An increased risk of bleeding Details Diclofenac Transdermal Patch Desvenlafaxine Pristiq An increased risk of bleeding Details Diclofenac Transdermal Patch Deutivacaftor Increased CYP2C9 substrate exposure Details Diclofenac Transdermal Patch Dexamethasone Increased risk of gastrointestinal ulcer or bleeding Details Diclofenac Transdermal Patch Dexketoprofen Increased risk of bleeding Details Diclofenac Transdermal Patch Diazoxide Proglycem Reduced diuretic effectiveness and possible nephrotoxicity Details Diclofenac Transdermal Patch Dibenzepin An increased risk of bleeding Details Diclofenac Transdermal Patch Diflunisal Dolobid Increased risk of bleeding Details Diclofenac Transdermal Patch Dipyridamole Permole® An increased risk of bleeding Details Diclofenac Transdermal Patch Dipyrone Increased risk of bleeding Details Diclofenac Transdermal Patch Dothiepin An increased risk of bleeding Details Diclofenac Transdermal Patch Doxepin Prudoxin An increased risk of bleeding Details Diclofenac Transdermal Patch Doxifluridine Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Diclofenac Transdermal Patch Droxicam Increased risk of bleeding Details Diclofenac Transdermal Patch Duloxetine An increased risk of bleeding Details Diclofenac Transdermal Patch Edoxaban Savaysa An increased risk of bleeding Details Diclofenac Transdermal Patch Emtricitabine Emtriva Increased emtricitabine exposure and an increased risk of emtricitabine-related adverse effects Details Diclofenac Transdermal Patch Enoxaparin Lovenox An increased risk of bleeding Details Diclofenac Transdermal Patch Eplerenone Inspra Reduced diuretic effectiveness, hyperkalemia, or possible nephrotoxicity Details Diclofenac Transdermal Patch Epoprostenol Flolan An increased risk of bleeding Details Diclofenac Transdermal Patch Eptifibatide An increased risk of bleeding Details Diclofenac Transdermal Patch Escitalopram Lexapro An increased risk of bleeding Details Diclofenac Transdermal Patch Ethacrynic Acid Edecrin Reduced diuretic effectiveness and possible nephrotoxicity Details Diclofenac Transdermal Patch Etodolac Lodine Increased risk of bleeding Details Diclofenac Transdermal Patch Etofenamate Increased risk of bleeding Details Diclofenac Transdermal Patch Etoricoxib Increased risk of bleeding Details Diclofenac Transdermal Patch Etozolin Reduced diuretic effectiveness and possible nephrotoxicity Details Diclofenac Transdermal Patch Felbinac Increased risk of bleeding Details Diclofenac Transdermal Patch Fenoprofen Fenopron Increased risk of bleeding Details Diclofenac Transdermal Patch Fepradinol Increased risk of bleeding Details Diclofenac Transdermal Patch Feprazone Increased risk of bleeding Details Diclofenac Transdermal Patch Feverfew Increased risk of adverse effects from the nonsteroidal antiinflammatory agent (ie, gastrointestinal, renal effects) Details Diclofenac Transdermal Patch Floctafenine Increased risk of bleeding Details Diclofenac Transdermal Patch Flufenamic Acid Increased risk of bleeding Details Diclofenac Transdermal Patch Fluorouracil Adrucil Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Diclofenac Transdermal Patch Fluoxetine RECONCILE An increased risk of bleeding Details Diclofenac Transdermal Patch Flurbiprofen Ansaid Increased risk of bleeding Details Diclofenac Transdermal Patch Fluvoxamine An increased risk of bleeding Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.