Diclofenac Transdermal Patch

268 interactions 703 cited references

Also sold as: Flector Flector® Patch Licart Licart ® Topical System Xiclo

About Diclofenac Transdermal Patch

Transdermal diclofenac is used to treat short-term pain due to minor strains, sprains, and bruises in adults and children 6 years of age and older. Diclofenac is in a class of medications called nonsteroidal anti-inflammatory drugs (NSAIDs). It works by stopping the body's production of a substance that causes pain. Read the full Diclofenac Transdermal Patch drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ketorolac Xipamide Fluorouracil Flufenamic Acid Floctafenine Feverfew

1 Contraindicated 197 Major 70 Moderate

All (268) Contraindicated (1) Major (197) Moderate (70)

Major

Diclofenac Transdermal Patch Fondaparinux Arixtra An increased risk of bleeding Details Diclofenac Transdermal Patch Furosemide Disal Reduced diuretic effectiveness and possible nephrotoxicity Details Diclofenac Transdermal Patch Gossypol Increased risk of adverse gastrointestinal effects Details Diclofenac Transdermal Patch Heparin An increased risk of bleeding Details Diclofenac Transdermal Patch Hydrochlorothiazide Inzirqo Reduced diuretic effectiveness and possible nephrotoxicity Details Diclofenac Transdermal Patch Hydrocortisone Ala-Cort Increased risk of gastrointestinal ulcer or bleeding Details Diclofenac Transdermal Patch Hydroflumethiazide Reduced diuretic effectiveness and possible nephrotoxicity Details Diclofenac Transdermal Patch Ibuprofen Addaprin Increased risk of bleeding Details Diclofenac Transdermal Patch Iloprost Aurlumyn An increased risk of bleeding Details Diclofenac Transdermal Patch Imipramine An increased risk of bleeding Details Diclofenac Transdermal Patch Indapamide Reduced diuretic effectiveness and possible nephrotoxicity Details Diclofenac Transdermal Patch Inotersen Increased risk of bleeding Details Diclofenac Transdermal Patch Ketoprofen Actron® Increased risk of bleeding Details Diclofenac Transdermal Patch Lepirudin An increased risk of bleeding Details Diclofenac Transdermal Patch Levoketoconazole Recorlev Increased risk of serious hepatotoxicity and drug-induced liver injury Details Diclofenac Transdermal Patch Levomilnacipran An increased risk of bleeding Details Diclofenac Transdermal Patch Lithium Increased lithium exposure and an increased risk of lithium toxicity Details Diclofenac Transdermal Patch Lofepramine An increased risk of bleeding Details Diclofenac Transdermal Patch Lornoxicam Increased risk of bleeding Details Diclofenac Transdermal Patch Loxoprofen Increased risk of bleeding Details Diclofenac Transdermal Patch Lumiracoxib Increased risk of bleeding Details Diclofenac Transdermal Patch Magnesium Salicylate Increased risk of bleeding Details Diclofenac Transdermal Patch Meadowsweet Increased risk of bleeding Details Diclofenac Transdermal Patch Meclofenamate Meclodium® Increased risk of bleeding Details Diclofenac Transdermal Patch Mefenamic Acid Ponstel® Increased risk of bleeding Details Diclofenac Transdermal Patch Melitracen An increased risk of bleeding Details Diclofenac Transdermal Patch Meloxicam Alloxate Increased risk of bleeding Details Diclofenac Transdermal Patch Melphalan Alkeran An increased risk of bleeding Details Diclofenac Transdermal Patch Mercaptopurine Purinethol® An increased risk of hepatotoxicity Details Diclofenac Transdermal Patch Mesalamine Apriso Increased risk of bleeding Details Diclofenac Transdermal Patch Methotrexate Jylamvo Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Diclofenac Transdermal Patch Methyclothiazide Reduced diuretic effectiveness and possible nephrotoxicity Details Diclofenac Transdermal Patch Methylprednisolone Depo-Medrol Increased risk of gastrointestinal ulcer or bleeding Details Diclofenac Transdermal Patch Metolazone Reduced diuretic effectiveness and possible nephrotoxicity Details Diclofenac Transdermal Patch Milnacipran Savella An increased risk of bleeding Details Diclofenac Transdermal Patch Morniflumate Increased risk of bleeding Details Diclofenac Transdermal Patch Nabumetone Relafen Increased risk of bleeding Details Diclofenac Transdermal Patch Nadroparin An increased risk of bleeding Details Diclofenac Transdermal Patch Naproxen Aleve Increased risk of bleeding Details Diclofenac Transdermal Patch Nefazodone An increased risk of bleeding Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.