Diclofenac Transdermal Patch

268 interactions 703 cited references

Also sold as: Flector Flector® Patch Licart Licart ® Topical System Xiclo

About Diclofenac Transdermal Patch

Transdermal diclofenac is used to treat short-term pain due to minor strains, sprains, and bruises in adults and children 6 years of age and older. Diclofenac is in a class of medications called nonsteroidal anti-inflammatory drugs (NSAIDs). It works by stopping the body's production of a substance that causes pain. Read the full Diclofenac Transdermal Patch drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ketorolac Xipamide Fluorouracil Flufenamic Acid Floctafenine Feverfew

1 Contraindicated 197 Major 70 Moderate

All (268) Contraindicated (1) Major (197) Moderate (70)

Major

Diclofenac Transdermal Patch Nepafenac Ilevro Increased risk of bleeding Details Diclofenac Transdermal Patch Niflumic Acid Increased risk of bleeding Details Diclofenac Transdermal Patch Nimesulide Increased risk of bleeding Details Diclofenac Transdermal Patch Nimesulide Beta Cyclodextrin Increased risk of bleeding Details Diclofenac Transdermal Patch Nortriptyline An increased risk of bleeding Details Diclofenac Transdermal Patch Olsalazine Dipentum Increased risk of bleeding Details Diclofenac Transdermal Patch Opipramol An increased risk of bleeding Details Diclofenac Transdermal Patch Oxaprozin Coxanto Increased risk of bleeding Details Diclofenac Transdermal Patch Oxyphenbutazone Increased risk of bleeding Details Diclofenac Transdermal Patch Parecoxib Increased risk of bleeding Details Diclofenac Transdermal Patch Parnaparin An increased risk of bleeding Details Diclofenac Transdermal Patch Paroxetine Paxil An increased risk of bleeding Details Diclofenac Transdermal Patch Pemetrexed Increased PEMEtrexed exposure and an increased risk of PEMEtrexed toxicity (myelosuppression, renal toxicity, and gastrointestinal... Details Diclofenac Transdermal Patch Pentosan Polysulfate Sodium An increased risk of bleeding Details Diclofenac Transdermal Patch Pentoxifylline Pentoxil® An increased risk of bleeding Details Diclofenac Transdermal Patch Phenindione An increased risk of bleeding Details Diclofenac Transdermal Patch Phenprocoumon An increased risk of bleeding Details Diclofenac Transdermal Patch Phenylbutazone Equi-Phar Increased risk of bleeding Details Diclofenac Transdermal Patch Phenyl Salicylate Increased risk of bleeding Details Diclofenac Transdermal Patch Piketoprofen Increased risk of bleeding Details Diclofenac Transdermal Patch Piretanide Reduced diuretic effectiveness and possible nephrotoxicity Details Diclofenac Transdermal Patch Piroxicam Feldene Increased risk of bleeding Details Diclofenac Transdermal Patch Polythiazide Reduced diuretic effectiveness and possible nephrotoxicity Details Diclofenac Transdermal Patch Potassium Citrate Urocit-K Increased risk of hyperkalemia Details Diclofenac Transdermal Patch Prasugrel Effient An increased risk of bleeding Details Diclofenac Transdermal Patch Prednisolone Flo-Pred® Increased risk of gastrointestinal ulcer or bleeding Details Diclofenac Transdermal Patch Prednisone Deltasone Increased risk of gastrointestinal ulcer or bleeding Details Diclofenac Transdermal Patch Proglumetacin Increased risk of bleeding Details Diclofenac Transdermal Patch Propyphenazone Increased risk of bleeding Details Diclofenac Transdermal Patch Proquazone Increased risk of bleeding Details Diclofenac Transdermal Patch Protein C Ceprotin An increased risk of bleeding Details Diclofenac Transdermal Patch Protriptyline An increased risk of bleeding Details Diclofenac Transdermal Patch Quinethazone Reduced diuretic effectiveness and possible nephrotoxicity Details Diclofenac Transdermal Patch Reviparin An increased risk of bleeding Details Diclofenac Transdermal Patch Rivaroxaban Xarelto An increased risk of bleeding Details Diclofenac Transdermal Patch Rofecoxib Increased risk of bleeding Details Diclofenac Transdermal Patch Salicylamide Increased risk of bleeding Details Diclofenac Transdermal Patch Salicylic Acid Increased risk of bleeding Details Diclofenac Transdermal Patch Salsalate Disalcid Increased risk of bleeding Details Diclofenac Transdermal Patch Selexipag Uptravi An increased risk of bleeding Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.