Dolasetron Injection and Atenolol: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Dolasetron Injection
Atenolol
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
An increased risk of dolasetron adverse effects (headache, hypotension, bradycardia, dizziness)
Interaction Deep Dive
Dolasetron is reduced to its active metabolite hydrodolasetron by the carbonyl reductase enzyme. Parent drug is rarely detected in the plasma due to rapid and complete metabolism to hydrodolasetron, the most clinically relevant metabolite. The clearance of hydrodolasetron was decreased by 27% when intravenous dolasetron was administered concurrently with atenolol1. The clinical significance of this interaction is not known.
Why it happens (mechanism)
Unknown
Common questions
Can I take Dolasetron Injection and Atenolol together?
An increased risk of dolasetron adverse effects (headache, hypotension, bradycardia, dizziness) Always confirm with your pharmacist or prescriber before making any change.
How serious is the Dolasetron Injection and Atenolol interaction?
It is rated minor. Usually limited clinical impact.
How quickly could this interaction happen?
The documented onset is "delayed". Effects tend to build up gradually over days to weeks.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
Questions for your pharmacist
- Does my dose of Dolasetron Injection or Atenolol need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there anything you'd monitor while I'm on both?
References (1)
- Product Information: Anzemet(R), dolasetron. Hoechst Marion Roussel, Inc. Kansas City, MO, 1997. DailyMed
Keep reading about Dolasetron Injection
Keep reading about Atenolol
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