Doxycycline

40 interactions 3 explained in plain English
Also sold as: Acticlate Acticlate CAP® Acticlate® Adoxa Alodox Avidoxy Doryx Doryx MPC® Doryx® Doxy Doxychel® Mondoxyne Monodox Monodox® Morgidox Okebo Oracea Oracea® Periostat Periostat® Targadox Vibra-Tabs® Vibramycin Vibramycin®
About Doxycycline

Doxycycline is a tetracycline antibiotic used to treat bacterial infections, acne, rosacea, and to prevent malaria and anthrax. Read the full Doxycycline drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jun 30, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Acitretin Ascorbic Acid (Vitamin C) Penicillin G Benzathine Injection Penicillin V Potassium Dabigatran Etexilate Heparin Injection
1 Contraindicated 31 Major 8 Moderate
All (40) Contraindicated (1) Major (31) Moderate (8)

Contraindicated

Doxycycline Acitretin Soriatane® An increased risk of pseudotumor cerebri (benign intracranial hypertension) Details

Major

Doxycycline Isotretinoin Absorica Explained An increased risk of pseudotumor cerebri (benign intracranial hypertension) Details Doxycycline Amoxicillin Amoxi Drop Decreased antibacterial effectiveness Details Doxycycline Ampicillin Amcill® Decreased antibacterial effectiveness Details Doxycycline Ampicillin Injection Omnipen-N® Decreased antibacterial effectiveness Details Doxycycline Apixaban Eliquis Explained An increased risk of bleeding Details Doxycycline Betrixaban Bevyxxa® An increased risk of bleeding Details Doxycycline Ascorbic Acid (Vitamin C) C-500® Chewable Tablet Decreased doxycycline efficacy Details Doxycycline Bexarotene Targretin An increased risk of pseudotumor cerebri (benign intracranial hypertension) Details Doxycycline Bexarotene Topical Targretin An increased risk of pseudotumor cerebri (benign intracranial hypertension) Details Doxycycline Dabigatran Pradaxa® An increased risk of bleeding Details Doxycycline Dabigatran Etexilate An increased risk of bleeding Details Doxycycline Dalteparin Injection Fragmin An increased risk of bleeding Details Doxycycline Edoxaban Savaysa An increased risk of bleeding Details Doxycycline Enoxaparin Lovenox An increased risk of bleeding Details Doxycycline Enoxaparin Injection Lovenox An increased risk of bleeding Details Doxycycline Estradiol Delestrogen Reduced efficacy of oral contraceptive Details Doxycycline Estradiol Topical Divigel Reduced efficacy of oral contraceptive Details Doxycycline Estradiol Transdermal Patch Alora® Reduced efficacy of oral contraceptive Details Doxycycline Exenatide Injection Bydureon Reduced oral antibiotics absorption and reduced efficacy of oral antibiotics Details Doxycycline Fondaparinux Arixtra An increased risk of bleeding Details Doxycycline Fondaparinux Injection Arixtra An increased risk of bleeding Details Doxycycline Heparin An increased risk of bleeding Details Doxycycline Heparin Injection Lipo-Hepin® An increased risk of bleeding Details Doxycycline Levonorgestrel After banger Reduced efficacy of oral contraceptive Details Doxycycline Levonorgestrel Intrauterine System Kyleena Reduced efficacy of oral contraceptive Details Doxycycline Methotrexate Jylamvo Increased methotrexate exposure, an increased risk of methotrexate toxicity, reduced active metabolite formation, possibly reduced... Details Doxycycline Methotrexate Injection Abitrexate® Increased methotrexate exposure, an increased risk of methotrexate toxicity, reduced active metabolite formation, possibly reduced... Details Doxycycline Nafcillin Injection Unipen® Injection Decreased antibacterial effectiveness Details Doxycycline Penicillin G Benzathine Injection Bicillin Decreased antibacterial effectiveness Details Doxycycline Penicillin G Procaine Injection Bactracillin G Decreased antibacterial effectiveness Details Doxycycline Penicillin V Potassium Beepen-VK® Decreased antibacterial effectiveness Details

Moderate

Doxycycline Omeprazole Gastrobim Explained Reduced doxycycline efficacy Details Doxycycline Dexlansoprazole Dexilant Reduced doxycycline efficacy Details Doxycycline Esomeprazole Nexium Reduced doxycycline efficacy Details Doxycycline Esomeprazole Injection Nexium Reduced doxycycline efficacy Details Doxycycline Glimepiride Amaryl Increased blood glucose lowering effect and increased risk of hypoglycemia Details Doxycycline Lansoprazole Prevacid Reduced doxycycline efficacy Details Doxycycline Lanthanum Fosrenol® Reduced bioavailability of tetracyclines Details Doxycycline Lixisenatide Injection Adlyxin® Delayed therapeutic effect Details

Check another drug

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist
Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.