Droxicam

92 interactions 5 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ketorolac Nasal Spray Ketorolac Ophthalmic Ketorolac Ketorolac Injection Dabigatran Etexilate Heparin Injection
4 Contraindicated 59 Major 28 Moderate 1 Minor
All (92) Contraindicated (4) Major (59) Moderate (28) Minor (1)

Major

Droxicam Hydrocortisone Ala-Cort Increased risk of gastrointestinal ulcer or bleeding Details Droxicam Hydrocortisone Injection A-Hydrocort® Increased risk of gastrointestinal ulcer or bleeding Details Droxicam Ibuprofen Addaprin Increased risk of bleeding Details Droxicam Iloprost Aurlumyn An increased risk of bleeding Details Droxicam Ketoprofen Actron® Increased risk of bleeding Details Droxicam Lithium Carbonate Lithobid Increased lithium exposure and an increased risk of lithium toxicity Details Droxicam Meclofenamate Meclodium® Increased risk of bleeding Details Droxicam Mefenamic Acid Ponstel® Increased risk of bleeding Details Droxicam Meloxicam Alloxate Increased risk of bleeding Details Droxicam Meloxicam Injection Alloxate Increased risk of bleeding Details Droxicam Melphalan Alkeran An increased risk of bleeding Details Droxicam Melphalan Injection Alkeran An increased risk of bleeding Details Droxicam Mesalamine Apriso Increased risk of bleeding Details Droxicam Mesalamine Rectal Canasa Increased risk of bleeding Details Droxicam Methotrexate Jylamvo Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Droxicam Methotrexate Injection Abitrexate® Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Droxicam Nabumetone Relafen Increased risk of bleeding Details Droxicam Naproxen Aleve Increased risk of bleeding Details Droxicam Pemetrexed Injection Alimta Increased PEMEtrexed exposure and an increased risk of PEMEtrexed toxicity (myelosuppression, renal toxicity, and gastrointestinal... Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.