Duvelisib

Name: Duvelisib Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

51 interactions 6 explained in plain English

Also sold as: Copiktra

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ketoconazole Topical Abametapir Buprenorphine Cyclosporine Ophthalmic Nifedipine Brexpiprazole

48 Major 3 Moderate

All (51) Major (48) Moderate (3)

Major

Duvelisib Maraviroc Selzentry Increased exposure of sensitive CYP3A4 substrates and risk of toxicity Details Duvelisib Methylergonovine Methergine Increased methylergonovine exposure and an increased risk of vasospasm, cerebral ischemia and/or ischemia of extremities Details Duvelisib Midazolam Nasal Spray Nayzilam Increased exposure of sensitive CYP3A4 substrates and risk of toxicity Details Duvelisib Midazolam Injection Nayzilam Increased exposure of sensitive CYP3A4 substrates and risk of toxicity Details Duvelisib Mitapivat Aqvesme Increased mitapivat exposure Details Duvelisib Nafcillin Injection Unipen® Injection Decreased duvelisib exposure Details Duvelisib Naloxegol Movantik Increased exposure of sensitive CYP3A4 substrates and risk of toxicity Details Duvelisib Nifedipine Adalat® Increased NIFEdipine exposure Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.