Elacestrant

123 interactions 283 cited references

Also sold as: Orserdu Orserdu®

About Elacestrant

Elacestrant is used to treat certain types of hormone receptor-positive breast cancer (breast cancer that depends on hormones such as estrogen to grow) in adults who have had disease progression following treatment with at least one other hormone therapies. Elacestrant is in a class of medications called estrogen recep… Read the full Elacestrant drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Mumps Virus Vaccine, Live Bacillus Of Calmette And Guerin Vaccine, Live Levoketoconazole Ensitrelvir Measles Virus Vaccine, Live Dengue Tetravalent Vaccine, Live

11 Contraindicated 106 Major 6 Moderate

All (123) Contraindicated (11) Major (106) Moderate (6)

Major

Elacestrant Relugolix Orgovyx Increased relugolix exposure Details Elacestrant Colchicine Colcrys Increased P-gp substrate exposure and an increased risk of P-gp substrate-related adverse effects Details Elacestrant Alpelisib Piqray Increased alpelisib exposure and an increased risk of alpelisib-related adverse effects and toxicity Details Elacestrant Cyclosporine Injection Atopica Increased elacestrant/cycloSPORINE exposure and an increased risk of elacestrant/cycloSPORINE-related adverse effects Details Elacestrant Cyclosporine Ophthalmic Cequa Increased elacestrant/cycloSPORINE exposure and an increased risk of elacestrant/cycloSPORINE-related adverse effects Details Elacestrant Dabigatran Pradaxa® Increased dabigatran exposure and an increased risk of bleeding Details Elacestrant Dabigatran Etexilate Increased dabigatran exposure and an increased risk of bleeding Details Elacestrant Digoxin Cardoxin® Increased P-gp substrate exposure and an increased risk of P-gp substrate-related adverse effects Details Elacestrant Doxorubicin Adriamycin Increased DOXOrubicin exposure and an increased risk of DOXOrubicin-related adverse reactions Details Elacestrant Adagrasib Krazati Increased CYP3A4 substrate exposure Details Elacestrant Adenovirus Vaccine Type 4, Live An increased risk of infection by the live vaccine Details Elacestrant Adenovirus Vaccine Type 7, Live An increased risk of infection by the live vaccine Details Elacestrant Apalutamide Erleada Reduced elacestrant exposure and reduced efficacy of elacestrant Details Elacestrant Aprepitant Aponvie Increased elacestrant exposure and an increased risk of elacestrant-related adverse effects Details Elacestrant Atazanavir Reyataz Increased elacestrant exposure and an increased risk of elacestrant-related adverse effects Details Elacestrant Avacopan Tavneos Increased CYP3A4 substrate exposure Details Elacestrant Boceprevir Increased elacestrant exposure and an increased risk of elacestrant-related adverse effects Details Elacestrant Bosentan Reduced elacestrant exposure and reduced efficacy of elacestrant Details Elacestrant Carbamazepine Carbatrol Reduced elacestrant exposure and reduced efficacy of elacestrant Details Elacestrant Cenobamate Xcopri Reduced elacestrant exposure and reduced efficacy of elacestrant Details Elacestrant Cholera Vaccine Ipol An increased risk of infection by the live vaccine Details Elacestrant Ciprofloxacin Increased elacestrant exposure and an increased risk of elacestrant-related adverse effects Details Elacestrant Clarithromycin Biaxin Increased elacestrant exposure and an increased risk of elacestrant-related adverse effects Details Elacestrant Cobicistat Tybost Increased elacestrant exposure and an increased risk of elacestrant-related adverse effects Details Elacestrant Conivaptan Vaprisol Increased elacestrant exposure and an increased risk of elacestrant-related adverse effects Details Elacestrant Crizotinib Xalkori Increased elacestrant exposure and an increased risk of elacestrant-related adverse effects Details Elacestrant Cyclosporine Atopica Increased elacestrant/cycloSPORINE exposure and an increased risk of elacestrant/cycloSPORINE-related adverse effects Details Elacestrant Diltiazem Cardizem Increased elacestrant exposure and an increased risk of elacestrant-related adverse effects Details Elacestrant Doxorubicin Hydrochloride Liposome Increased DOXOrubicin exposure and an increased risk of DOXOrubicin-related adverse reactions Details Elacestrant Dronedarone Multaq Increased elacestrant exposure and an increased risk of elacestrant-related adverse effects Details Elacestrant Ebola Zaire Vaccine, Live An increased risk of infection by the live vaccine Details Elacestrant Efavirenz Reduced elacestrant exposure and reduced efficacy of elacestrant Details Elacestrant Encorafenib Braftovi Reduced CYP3A4 substrate exposure and reduced efficacy of CYP3A4 substrate Details Elacestrant Ensartinib Increased ensartinib exposure Details Elacestrant Enzalutamide Xtandi Reduced elacestrant exposure and reduced efficacy of elacestrant Details Elacestrant Erythromycin Erythrocin Stearate Increased elacestrant exposure and an increased risk of elacestrant-related adverse effects Details Elacestrant Etravirine Intelence Reduced elacestrant exposure and reduced efficacy of elacestrant Details Elacestrant Everolimus Afinitor Increased P-gp substrate exposure and an increased risk of P-gp substrate-related adverse effects Details Elacestrant Fluconazole Diflucan Increased elacestrant exposure and an increased risk of elacestrant-related adverse effects Details Elacestrant Fluoroestradiol F 18 Reduced detection of estrogen receptor (ER)-positive lesions Details

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