Elinzanetant and Ketoconazole Topical: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Ketoconazole Topical
Elinzanetant
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Increased elinzanetant exposure and an increased risk of elinzanetant-related adverse reactions
Interaction Deep Dive
Avoid concomitant use of elinzanetant (CYP3A4 substrate) with strong CYP3A4 inhibitors as it may increase elinzanetant exposure, which may increase the risk of elinzanetant adverse reactions. In a drug interaction study, coadministration of elinzanetant with itraconazole 200 mg (strong CYP3A4 inhibitor) increased elinzanetant Cmax and AUC by approximately 3.3-fold and 6.3-fold1.
Why it happens (mechanism)
Inhibition of CYP3A4-mediated metabolism of elinzanetant
Literature reports
1 report — tap to read
a) In a drug interaction study, coadministration of elinzanetant with itraconazole 200 mg (strong CYP3A4 inhibitor) increased elinzanetant Cmax and AUC by approximately 3.3-fold and 6.3-fold 1.
Common questions
Can I take Elinzanetant and Ketoconazole Topical together?
Increased elinzanetant exposure and an increased risk of elinzanetant-related adverse reactions Always confirm with your pharmacist or prescriber before making any change.
How serious is the Elinzanetant and Ketoconazole Topical interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
Questions for your pharmacist
- Does my dose of Elinzanetant or Ketoconazole Topical need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (1)
- Product Information: LYNKUET® oral capsules, elinzanetant oral capsules. Bayer HealthCare Pharmaceuticals Inc (per Manufacturer), Whippany, NJ, 2025. DailyMed
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