Encorafenib and Dordaviprone: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Encorafenib
Dordaviprone
No brand names on record
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
An increased risk of QT interval prolongation, reduced dordaviprone exposure and reduced efficacy of dordaviprone
Interaction Deep Dive
Avoid concomitant use of dordaviprone with strong or moderate CYP3A4 inducer that prolong the QT interval as it may cause additive QT interval prolongation, may reduce dordaviprone exposure, which may reduce the anti-tumor activity of dordaviprone. Dordaviprone causes concentration dependent QTc interval prolongation and may also increase the risk of QTc-associated arrhythmias. If concomitant use cannot be avoided, separate administration of dordaviprone and the QT prolonging product. Monitor ECGs and electrolytes prior to starting dordaviprone and then periodically during treatment. Interrupt or reduce the dose of dordaviprone in patients who develop QT prolongation, and permanently discontinue dordaviprone in patients with signs of life-threatening arrhythmias. In drug interaction studies, dordaviprone Cmax is predicted to decrease by 68% and AUC by 83% following concomitant administration of rifAMPin (strong CYP3A4 inducer) and dordaviprone Cmax is predicted to decrease by 44% and AUC by 65% following concomitant administration of efavirenz (moderate CYP3A4 inducer)1.
Why it happens (mechanism)
Additive QT interval prolongation; induction of CYP3A4-mediated metabolism of dordaviprone
Literature reports
1 report — tap to read
a) In drug interaction studies, dordaviprone Cmax is predicted to decrease by 68% and AUC by 83% following concomitant administration of rifAMPin (strong CYP3A4 inducer) and dordaviprone Cmax is predicted to decrease by 44% and AUC by 65% following concomitant administration of efavirenz (moderate CYP3A4 inducer) 1.
Common questions
Can I take Encorafenib and Dordaviprone together?
An increased risk of QT interval prolongation, reduced dordaviprone exposure and reduced efficacy of dordaviprone Always confirm with your pharmacist or prescriber before making any change.
How serious is the Encorafenib and Dordaviprone interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
Questions for your pharmacist
- Does my dose of Encorafenib or Dordaviprone need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (1)
- Product Information: MODEYSO(TM) oral capsules, dordaviprone oral capsules. Jazz Pharmaceuticals, Inc. (per manufacturer), Palo Alto, CA, 2025. DailyMed
Keep reading about Encorafenib
Keep reading about Dordaviprone
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Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
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