Encorafenib and Sparsentan: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Encorafenib
Sparsentan
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Reduced sparsentan exposure and reduced efficacy of sparsentan
Interaction Deep Dive
Avoid concomitant use of sparsentan (a CYP3A substrate) with strong CYP3A inducers. Concomitant use of sparsentan with a strong CYP3A inducer reduces sparsentan Cmax and AUC, which may reduce sparsentan efficacy. In a study, concomitant use of sparsentan (a strong CYP3A substrate) with rifampin (a strong CYP3A inducer) was predicted to decrease sparsentan Cmax by 23% and AUC(0 to inf) by 47% at steady state1.
Why it happens (mechanism)
Induction of CYP3A-mediated metabolism of sparsentan
Literature reports
1 report — tap to read
a) In a study, concomitant use of sparsentan (a CYP3A substrate) with rifampin (a strong CYP3A inducer) was predicted to decrease sparsentan Cmax by 23% and AUC(0 to inf) by 47% at steady state 1.
Common questions
Can I take Encorafenib and Sparsentan together?
Reduced sparsentan exposure and reduced efficacy of sparsentan Always confirm with your pharmacist or prescriber before making any change.
How serious is the Encorafenib and Sparsentan interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
Questions for your pharmacist
- Does my dose of Encorafenib or Sparsentan need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (1)
- Product Information: FILSPARI® oral tablets, sparsentan oral tablets. Travere Therapeutics Inc, San Diego, CA, 2026. DailyMed
Keep reading about Encorafenib
Keep reading about Sparsentan
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