Drug Interaction Report

Feprazone and Ketorolac Ophthalmic: Interaction Details

Name: Feprazone and Ketorolac Ophthalmic Interaction
Creator: Dr. Brian Staiger, PharmD, BCPS

A pharmacist-reviewed analysis of the Feprazone and Ketorolac Ophthalmic interaction: the documented clinical effects, severity rating, onset, mechanism, and management considerations, with cited references throughout.

AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature

Ketorolac Ophthalmic

Acular Acular® Acuvail Acuvail®

Feprazone

No brand names on record

Medically reviewed by

Dr. Brian Staiger, PharmD, BCPS

Updated Aug 8, 2026

Editorial policy · Data sources

Interaction severity

Contraindicated

These should generally not be used together.

Minor

Moderate

Major

Contraindicated

How we grade severity & evidence

Severity levels

Contraindicated: These should generally not be used together.
Major: Potentially serious — often needs a change or close monitoring.
Moderate: Can be significant — usually manageable with monitoring.
Minor: Usually limited clinical impact.

Evidence grades

Established: Well documented — supported by controlled studies or strong clinical data.
Probable: Good supporting evidence, though not definitively proven.
Suspected: Some evidence suggests this interaction, but it is not well established.
Possible: Limited or conflicting evidence; the interaction may occur.
Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.

Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.

Of 91 documented Feprazone interactions, 4 are rated contraindicated — including this one.

Worried about symptoms right now? Contact your pharmacist or prescriber, or call Poison Control at 1-800-222-1222 (US). Call 911 for an emergency.

Onset

rapid

Evidence

theoretical

Severity

Contraindicated

What happens

Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation)

Interaction Deep Dive

Ketorolac oral or IV is contraindicated in patients currently receiving aspirin or NSAIDs because of the cumulative risks of inducing serious NSAID-related adverse events (peptic ulcers, gastrointestinal (GI) bleeding and/or perforation)³¹. Concomitant use of the nasal spray with other NSAIDs is not recommended due an increased risk for GI toxicity with little or no improvement in efficacy ².

Why it happens (mechanism)

Additive gastrointestinal irritation

Common questions

Can I take Feprazone and Ketorolac Ophthalmic together?

Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Always confirm with your pharmacist or prescriber before making any change.

How serious is the Feprazone and Ketorolac Ophthalmic interaction?

It is rated contraindicated. These should generally not be used together.

How quickly could this interaction happen?

The documented onset is "rapid". Effects can appear quickly, often within about 24 hours of combining the drugs.

How strong is the evidence for this interaction?

The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.

Questions for your pharmacist

Does my dose of Feprazone or Ketorolac Ophthalmic need adjusting while I take them together?
What symptoms should prompt me to call you or my prescriber right away?
Does the timing of my doses matter for this combination?
Is there a safer alternative to one of these medications for me?

References (3)

Product Information: ketorolac tromethamine IV, IM injection, ketorolac tromethamine IV, IM injection. Bedford Laboratories (TM), Bedford, OH, 2009.
Product Information: SPRIX(R) nasal spray, ketorolac tromethamine nasal spray. Egalet US Inc. (per FDA), Wayne, PA, 2016. DailyMed
Product Information: ketorolac tromethamine oral film coated tablets, ketorolac tromethamine oral film coated tablets. Teva Pharmaceuticals USA (per Dailymed), Sellersville, PA, 2009. DailyMed

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Ketorolac Ophthalmic

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HelloPharmacist doesn't license one of the big commercial interaction databases, so what you'll find here is not a complete list of every known drug interaction. Instead, each entry is researched, analyzed, and written up individually — documented from the published literature, reviewed by a pharmacist, and cited so you can check every source yourself.

If a combination isn't listed here, it means we haven't documented it yet — never that it's safe. For screening a full medication list, we recommend pairing this site with a comprehensive tool like the Drugs.com Interaction Checker and, most importantly, a review by your own pharmacist. For a deep, plain-English, fully sourced explanation of a specific documented interaction — that's exactly what we built this for.

This information is for education, not a substitute for professional medical advice. Do not start, stop, or change any medication without talking to your pharmacist or prescriber.